Author

P. V. Holec

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Assay:CITE-seq· 2 Organism:human· 2 Research Focus:clustering· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1

Frequent Co-Authors

M. E. Birnbaum· 3 shared C. G. Rappazzo· 2 shared D. J. Irvine· 2 shared K. S. Gordon· 2 shared T. Kyung· 2 shared A. Marc· 1 shared A. Q. Zhang· 1 shared A. Ramos· 1 shared

Activity by Year

2020-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersImmunology

M. E. Birnbaum

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3 papers

Recent·Most cited

Identification of highly cross-reactive mimotopes for a public T cell response in murine melanoma

B. E. Grace, C. M. Backlund, D. M. Morgan, B. H. Kang, N. K. Singh, B. D. Huisman, C. G. Rappazzo, K. D. Moynihan, L. Maiorino, C. S. Dobson, T. Kyung, K. S. Gordon, P. V. Holec, O. C. T. Mbah, D. Garafola, , M. E. Birnbaum

The paper identifies a dominant tumor-associated antigen in murine melanoma and shows that engineered mimotopes can induce cross-reactive T cell responses.

bioRxiv · Feb 28, 2022Immunology

CARPOOL: A library-based platform to rapidly identify next generation chimeric antigen receptors

T. Kyung, K. S. Gordon, C. R. Perez, P. V. Holec, A. Ramos, A. Q. Zhang, Y. Liu, C. Koch, A. Starchenko, B. Joughin, D. A. Lauffenburger, D. J. Irvine, M. T. Hemann, M. E. Birnbaum

The paper develops a library-based platform to identify optimized chimeric antigen receptors (CARs) with improved anti-tumor functions through high-throughput screening of diverse signaling domains.

bioRxiv · Jul 9, 2021Immunology

Vaccination reshapes the virus-specific T cell repertoire in unexposed adults

Y.-G. Pan, B. Aiamkitsumrit, L. Bartolo, Y. Wang, C. Lavery, A. Marc, P. V. Holec, C. G. Rappazzo, T. Eilola, P. A. Gimotty, S. E. Hensley, R. Antia, V. I. Zarnitsyna, M. E. Birnbaum, L. F. Su

This study examines how pre-existing T cell characteristics influence the immune response to a yellow fever vaccine, finding that memory T cells and rare populations shape post-vaccination responses.

bioRxiv · Oct 1, 2020Immunology