M. Solotchi

The NS1 protein of influenza B virus binds 5'-triphosphorylated dsRNA to suppress RIG-I activation and the antiviral innate immune response

RIG-I uses its intrinsically disordered CARDs-Helicase linker in RNA proofreading functions

This study identifies a proofreading mechanism in RIG-I that uses the CARDs-Helicase Linker to gate RNA specificity and stabilize interactions, preventing non-specific RNA engagement.