This study introduces microsecond pulse electric field (sPEF) to enhance wound healing by promoting fibroblast migration and ECM alignment, validated in 2D and 3D models and a mouse wound healing assay.

bioRxiv · Oct 23, 2022Bioengineering

mTOR Inhibition Overcomes RSK3-mediated Resistance to BET Inhibitors in Small Cell Lung Cancer

A. Kumari, L. Gesumaria, Y.-J. Liu, V. K. Hughitt, X. Zhang, M. Ceribelli, K. M. Wilson, C. Klumpp-Thomas, L. Chen, C. McKnight, Z. Itkin, C. Thomas, B. A. Mock, D. S. Schrump, H. Chen

This study identifies mTOR inhibition as a strategy to overcome RSK3-mediated resistance to BET inhibitors in small cell lung cancer, enhancing apoptosis and antitumor efficacy.

bioRxiv · Nov 8, 2021Cancer Biology

Targeting metabolic adaptations in the breast cancer liver metastatic niche using dietary approaches to improve endocrine therapy efficacy

Q. Zuo, A. N. Mogol, Y.-J. Liu, A. S. Casiano, C. Chien, J. Drnevich, O. B. Imir, E. Kulkoyluoglu-Cotul, N. H. Park, D. J. Shapiro, B. H. Park, Y. Ziegler, B. S. Katzenellenbogen, E. Aranda, J. D. O'Neill, , Z. Madak-Erdogan

This study identifies a mechanism of endocrine resistance in liver metastases of ER+ breast cancer and shows that a fasting-mimicking diet enhances the efficacy of fulvestrant treatment.

bioRxiv · Sep 7, 2021Cancer Biology

A Novel SARS-CoV-2 Multitope Protein/Peptide Vaccine Candidate is Highly Immunogenic and Prevents Lung Infection in an AAV hACE2 Mouse Model and non-human primates

F. Guirakhoo, L. Kuo, J. Peng, J. H. Huang, B. Kuo, F. Lin, Y.-J. Liu, Z. Liu, G. Wu, S. Ding, K.-L. Hou, J. Cheng, V. Yang, H. Jiang, J. Wang, , C. Y. Wang

This paper describes a multitope protein-peptide vaccine candidate, UB-612, that is immunogenic and prevents lung infection in animal models, with ongoing clinical trials.

bioRxiv · Nov 30, 2020 · PreprintImmunology