Author

B. Orsetti

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Organism:human· 4 Assay:bulk RNA-seq· 3 Research Focus:cancer & tumor microenvironment· 3 Approach:experimental assay· 3 Research Focus:cell signaling & trafficking· 1 Assay:DNA methylation· 1 Approach:genetic perturbation / CRISPR· 1 Research Focus:host-pathogen & immune response· 1

Frequent Co-Authors

C. Theillet· 3 shared C. Sardet· 2 shared J. Colinge· 2 shared L. Fenou· 2 shared W. Jacot· 2 shared A. Abi-Khalil· 1 shared A. Bender· 1 shared A. Djiane· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersCancer Biology

C. Theillet

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Author profile →

4 papers

Recent·Most cited

Deciphering Oxygen Distribution and Hypoxia Profiles in the Tumor Microenvironment: A Data-Driven Mechanistic Modeling Approach

P. Kumar, M. Lacroix, P. Dupre, J. Arslan, L. Fenou, B. Orsetti, L. Le Cam, D. Racoceanu, O. Radulescu

The paper develops a data-driven mechanistic model to quantify hypoxia profiles in tumors using reaction-diffusion equations and vascular data.

bioRxiv · Mar 4, 2024Cancer Biology

Replication poison treated BRCA1-deficient breast cancers are prone to MRE11 over-resection resulting in single strand DNA accumulation and mitotic catastrophe

I. Tabet, E. Orhan, E. Candiello, L. Fenou, C. Velazquez, B. Orsetti, G. Rodier, W. Jacot, C. Ribeyre, C. Sardet, C. Theillet

This study shows BRCA1-deficient breast cancers are highly sensitive to gemcitabine, leading to ssDNA accumulation and mitotic catastrophe, which may enhance antitumor immune response.

bioRxiv · Oct 31, 2023 · PreprintCancer Biology

MAGI1 inhibits the AMOTL2/p38 stress pathway and prevents luminal breast tumorigenesis

D. Kantar, E. Bousquet Mur, M. Mancini, V. Slaninova, Y. Ben Salah, L. Costa, E. Forest, P. Lassus, C. Geminard, F. Boissiere-Michot, B. Orsetti, C. Theillet, J. Colinge, C. Benistant, A. Maraver, , A. Djiane

The paper shows that MAGI1 loss in luminal breast cancer promotes tumorigenesis by activating the AMOTL2/p38 stress pathway, which is inhibited by MAGI1.

bioRxiv · Jun 13, 2020Cancer Biology

Distinct oncogenes drive distinct genome and epigenome alterations in human mammary epithelial cells

C. Fonti, A. Saumet, A. Abi-Khalil, B. Orsetti, W. Jacot, E. Cleroux, A. Bender, M. Dumas, E. Schmitt, J. Colinge, M. Weber, C. Sardet, S. du Manoir, C. Theillet

This study shows that activating different oncogenes in human mammary epithelial cells leads to distinct genetic and epigenetic changes, suggesting oncogene activation shapes breast cancer subtypes.

International Journal of Cancer · Jun 10, 2019Peer-reviewedCancer Biology