Y. Hong

JNK1 And Downstream Signalling Hubs Regulate Anxiety-Like Behaviours In A Zebrafish Larvae Phenotypic Screen

The paper identifies JNK1 downstream signalling hubs that regulate anxiety-like behaviours in zebrafish larvae using a behavioural assay and phosphoproteome analysis.

Development of a Two-Leaf Photosynthetic Model Sensitive to Chlorophyll and Its Coupling with a Wheat Growth Model

This study develops a two-leaf photosynthetic model sensitive to chlorophyll and couples it with a wheat growth model to better understand the effects of nitrogen dynamics and diffuse light on photosynthesis.

Synchronization of Circadian Clock Gene Expression in Arabidopsis and Hyaloperonospora arabidopsidis and its Impact on Host-Pathogen Interactions

This study identifies circadian clock genes in the oomycete pathogen Hpa and shows their synchronization with host Arabidopsis clock genes, impacting virulence.

Stimulated Prorocentrum donghaiense cell growth by in-situ mariculture dissolved organic matter

This study shows that in-situ mariculture dissolved organic matter promotes growth and photosynthesis of Prorocentrum donghaiense through absorbtrophy, with bacterioplankton playing helper and competitor roles.

Deciphering the molecular mechanism underlying morphology transition in two-component DNA-protein cophase separation

The paper investigates DNA-protein co-condensates, identifying two morphology transitions and growth dynamics governed by DNA-p53 interaction strength.

Lactose and its derivatives are a new class of immune checkpoint inhibitors for cancer therapy

This study identifies lactose and its derivatives as immune checkpoint inhibitors by enhancing CD8+ T-cell function through modulation of galactosylation and Gal-1 interactions.

Determining glycosyltransferase functional order via lethality due to accumulated O-antigen intermediates, exemplified with Shigella flexneri O-antigen biosynthesis

The paper introduces a genetic approach to determine the functional order of glycosyltransferases in O-antigen biosynthesis using Shigella flexneri, identifying RfbG and RfbF as key enzymes in the assembly of the OAg repeating unit.

Interpretable Inflammation Landscape of Circulating Immune cells

This paper constructs a single-cell atlas of circulating immune cells to understand inflammation across diseases and develops a classifier for inflammatory diseases.

Identification of A Potential Inhibitor for Anticancer Target MTHFD2 by Consensus Docking and Molecular Dynamics

This study identifies E96 as a potential inhibitor of MTHFD2 through consensus docking and molecular dynamics, showing it outperforms other compounds in binding stability and free energy.

Respiration and growth of Paracoccus denitrificans R-1 with nitrous oxide as an electron acceptor

This study investigates the ability of Paracoccus denitrificans R-1 to use nitrous oxide as an electron acceptor for energy generation and growth, showing it can reduce N2O to N2 under anaerobic conditions.

Single-cell RNA sequencing unveils the hidden powers of zebrafish kidney for generating both hematopoiesis and adaptive antiviral immunity

This study uses single-cell RNA sequencing to show zebrafish kidney cells can generate both blood cells and adaptive antiviral immunity, acting as a dual-functional organ.

Chromatinization Modulates Topoisomerase II Processivity

This study shows that chromatin enhances topoisomerase II processivity under both high and low torsional stress, with topo II relaxing over 6000 DNA turns on plectonemic DNA.

Hallmark molecular and pathological features of POLG disease are recapitulated in cerebral organoids

This paper develops a cerebral organoid model of POLG disease that recapitulates its molecular and pathological features, including mtDNA depletion and neuronal loss, and shows metformin can alleviate some abnormalities.

Extensive diversity in Escherichia coli Group 3 capsules is driven by recombination and plasmid transfer from multiple species

The paper identifies seven new Group 3 capsule gene clusters in E. coli, revealing extensive diversity driven by recombination and plasmid transfer from multiple species.

Chemotherapeutic regulation of the ROS/MondoA-dependent TXNIP/GDF15 axis; and derivation of a new organoid metric as a predictive biomarker

The paper identifies chemotherapy-induced TXNIP as a negative regulator of GDF15 in CRC, showing its potential as a prognostic biomarker through organoid models.

O antigen biogenesis sensitises Escherichia coli K-12 to bile salts, a likely cause for how it lost its O antigen

This study shows that restoring O antigen in E. coli K-12 sensitizes it to bile salts and vancomycin, suggesting bile salts drove the loss of O antigen in K-12 strains.

Novel Anammox Bacteria Discovered in the Untapped Subsurface Aquifers

The paper discovers new anammox bacteria in aquifers, expands taxonomic diversity, and highlights their role in nitrogen cycling.

Attractant and repellent induce opposing changes in the chemoreceptor four-helix bundle ligand-binding domain

The paper identifies malate as a repellent recognized by the MCP2021 chemoreceptor in Comamonas testosteroni and shows how it induces opposing conformational changes compared to the attractant citrate.

Artificially cultivated duckweed: a high-efficiency starch producer

This paper reports a method to produce starch efficiently from duckweed under specific conditions and identifies mechanisms behind its high starch accumulation.

Identification and characterization of structural and regulatory cell-shape determinants in Haloferax volcanii

The paper identifies and characterizes proteins involved in cell-shape determination in Haloferax volcanii using proteomics, genetics, and live-cell imaging.

Bacterial suppressor-of-copper-sensitivity (Scs) proteins exhibit diverse thiol-disulfide oxidoreductase cellular functions

This study shows that ScsC proteins, despite structural differences, exhibit both dithiol oxidation and disulfide reduction activity, with oxidase activity dependent on environmental oxidation.

A General Fluorescence-Based Method for Quantifying and Mapping Biomolecular Polarity In Vitro and In Cells

This paper introduces a fluorescence-based method to quantify and map biomolecular polarity in vitro and in cells, showing that polarity varies with phase separation types and stress conditions.

Mutation-induced phenotypic plasticity drives formation of a pro-metastatic tumour-intrinsic niche

This study identifies mutation-induced phenotypic plasticity as a driver of a pro-metastatic tumour-intrinsic niche in BRAF-mutant colorectal cancer.

Lineage-mosaic and mutation-patched spike proteins for broad-spectrum COVID-19 vaccine

This study develops a bivalent vaccine using lineage-mosaic and mutation-patched spike proteins that elicit broad-spectrum antibodies and protect against multiple SARS-CoV-2 variants in hamsters.

Inhibition of ADORA1 attenuates hepatic steatosis by gut microbiota-derived acetic acid from Astragalus polysaccharides

The paper reports that some data could not be replicated and the manuscript was withdrawn, with parts of the data published elsewhere.

Matrix Softening Controls Stretch-Induced Cellular Memory and Fibroblast Activation

This study shows that matrix softening influences stretch-induced cellular memory and fibroblast activation, with a model predicting activation levels based on ECM properties.

Mis-regulation of Zn and Mn homeostasis is a key phenotype of Cu stress in Streptococcus pyogenes.

This study shows that Cu stress in GAS leads to mis-regulation of Zn and Mn homeostasis, affecting growth and lactate secretion, without altering cellular Cu levels.

Cysteine dependent conformation heterogeneity of Shigella flexneri autotransporter IcsA and implications in its function

This paper investigates the role of cysteine residues in Shigella IcsA's conformational changes, showing how they influence adhesin activity and immune evasion.

Noninvasive cancer detection by extracting and integrating multi-modal data from whole-methylome sequencing of plasma cell-free DNA

This paper develops a method to detect cancer noninvasively by integrating methylation, fragmentation, and copy number data from plasma cell-free DNA using machine learning.

Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball patterned arrays

This study develops Stereo-seq, a high-resolution spatial transcriptomic method, to analyze mouse organogenesis and map developmental disease loci.