Author

B. Zhan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Microbiology· 2 Zoology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 5 Research Focus:host-pathogen & immune response· 4 Research Focus:drug response / drug discovery· 2 Organism:human· 2 Organism:mouse· 2 Research Focus:differential expression· 1 Assay:protein sequence· 1

Frequent Co-Authors

M. E. Bottazzi· 4 shared J. Altieri Rivera· 3 shared J. Lee· 3 shared J. Wei· 3 shared P. J. Hotez· 3 shared P. M. Gillespie· 3 shared R. Adhikari· 3 shared U. Strych· 3 shared

Activity by Year

2020-2024 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

M. E. Bottazzi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Evaluation of a novel Tc-24 recombinant antigen ELISA for serologic testing for Trypanosoma cruzi in dogs

R. Mejia, G. G. Verocai, I. A. Mosley, B. Zhan, L. Vongthavaravat, R. E. Busselman, S. A. Hamer

This study evaluates a new Tc-24 recombinant antigen ELISA for detecting anti-T. cruzi antibodies in dogs, showing high sensitivity and specificity compared to existing tests.

bioRxiv · Feb 12, 2024 · PreprintZoology

Alnustone inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A

C. Zhang, T. Fang, X. Wang, L. Shi, B. Zhan, N. Hou, S. Liu, M. Bao, G. Chi

This study identifies alnustone as a drug that inhibits Streptococcus pneumoniae virulence by targeting pneumolysin and sortase A, reducing biofilm formation and protecting against infection.

bioRxiv · Mar 7, 2022Microbiology

Plasmodium falciparum and helminth coinfections increase IgE and parasite-specific IgG responses

R. Santano, R. Rubio, B. Grau-Pujol, V. Escola, O. Muchisse, I. Cuamba, M. Vidal, P. Cistero, G. Ruiz-Olalla, R. Aguilar, M. Demontis, J. C. Jamine, A. Cossa, C. Sacoor, J. Cano, , C. Dobano

This study examines how co-infections with Plasmodium falciparum and helminths affect antibody responses in Mozambican individuals, finding increased IgE and IgG levels in co-infected individuals.

bioRxiv · May 26, 2021Immunology

Process Development and Scale-up Optimization of the SARS-CoV-2 Receptor Binding Domain-Based Vaccine Candidate, RBD219-N1C1

J. Lee, Z. Liu, W.-H. Chen, J. Wei, R. Kundu, R. Adhikari, J. Altieri Rivera, P. M. Gillespie, U. Strych, B. Zhan, P. J. Hotez, M. E. Bottazzi

The paper optimizes the production process for a SARS-CoV-2 vaccine candidate, achieving high yield and purity through yeast fermentation and chromatographic purification.

bioRxiv · Dec 30, 2020Immunology

Genetic Modification to Design a Stable Yeast-expressed Recombinant SARS-CoV-2 Receptor Binding Domain as a COVID-19 Vaccine Candidate

W.-H. Chen, J. Wei, R. T. Kundu, R. Adhikari, Z. Liu, J. Lee, L. Versteeg, C. Poveda, B. Keegan, M. J. Villar, A. C. de Araujo Leao, J. Altieri Rivera, P. M. Gillespie, J. Pollet, U. Strych, , M. E. Bottazzi

The paper genetically modifies SARS-CoV-2 RBD variants in yeast to identify a more stable and manufacturable vaccine candidate.

bioRxiv · Nov 9, 2020Immunology

SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice

J. Pollet, W.-H. Chen, L. Versteeg, B. Keegan, B. Zhan, J. Wei, Z. Liu, J. Lee, R. Kundu, R. Adhikari, C. Poveda, M. J. Villar Mondragon, A. C. de Araujo Leao, J. Altieri Rivera, Z. Momin, , M. E. Bottazzi

This study develops a yeast-expressed SARS-CoV-2 RBD protein vaccine candidate, RBD219-N1C1, which induces neutralizing antibodies and T-cell responses in mice.

bioRxiv · Nov 4, 2020Immunology

Schistosoma haematobium extracellular vesicle proteins confer protection in a heterologous model of schistosomiasis

G. G. Mekonnen, B. A. Tedla, D. Pickering, L. Becker, L. Wang, B. Zhan, M. E. Bottazzi, A. Loukas, J. Sotillo, M. S. Pearson

The paper identifies extracellular vesicle proteins from Schistosoma haematobium and shows that vaccinating mice with recombinant tetraspanins reduces egg burdens in a heterologous schistosomiasis model.

Vaccines · Jul 24, 2020Peer-reviewedMicrobiology