Author

P. J. Hotez

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1 Pathology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 7 Organism:mouse· 4 Assay:proteomics· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

M. E. Bottazzi· 7 shared U. Strych· 5 shared J. Pollet· 4 shared W.-H. Chen· 4 shared Z. Liu· 4 shared B. Zhan· 3 shared C. Poveda· 3 shared J. Altieri Rivera· 3 shared

Activity by Year

2020-2023 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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7 shared papersImmunology

M. E. Bottazzi

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

The impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection

K. Jones, D. M. Nguyen, C. Poveda, J. Pollet, F. Gusovsky, M. E. Bottazzi, P. J. Hotez

This study evaluates the impact of vaccine-linked chemotherapy on liver health in a mouse model of chronic Trypanosoma cruzi infection, finding that the treatment better preserves liver health compared to curative doses of benznidazole.

bioRxiv · Jul 11, 2023Pathology

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

bioRxiv · May 20, 2021Immunology

Process Development and Scale-up Optimization of the SARS-CoV-2 Receptor Binding Domain-Based Vaccine Candidate, RBD219-N1C1

J. Lee, Z. Liu, W.-H. Chen, J. Wei, R. Kundu, R. Adhikari, J. Altieri Rivera, P. M. Gillespie, U. Strych, B. Zhan, P. J. Hotez, M. E. Bottazzi

The paper optimizes the production process for a SARS-CoV-2 vaccine candidate, achieving high yield and purity through yeast fermentation and chromatographic purification.

bioRxiv · Dec 30, 2020Immunology

Genetic Modification to Design a Stable Yeast-expressed Recombinant SARS-CoV-2 Receptor Binding Domain as a COVID-19 Vaccine Candidate

W.-H. Chen, J. Wei, R. T. Kundu, R. Adhikari, Z. Liu, J. Lee, L. Versteeg, C. Poveda, B. Keegan, M. J. Villar, A. C. de Araujo Leao, J. Altieri Rivera, P. M. Gillespie, J. Pollet, U. Strych, , M. E. Bottazzi

The paper genetically modifies SARS-CoV-2 RBD variants in yeast to identify a more stable and manufacturable vaccine candidate.

bioRxiv · Nov 9, 2020Immunology

SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice

J. Pollet, W.-H. Chen, L. Versteeg, B. Keegan, B. Zhan, J. Wei, Z. Liu, J. Lee, R. Kundu, R. Adhikari, C. Poveda, M. J. Villar Mondragon, A. C. de Araujo Leao, J. Altieri Rivera, Z. Momin, , M. E. Bottazzi

This study develops a yeast-expressed SARS-CoV-2 RBD protein vaccine candidate, RBD219-N1C1, which induces neutralizing antibodies and T-cell responses in mice.

bioRxiv · Nov 4, 2020Immunology

Alterations to the cardiac metabolome induced by chronic T. cruzi infection relate to the degree of cardiac pathology

K. A. Hoffman, P. J. Hotez, M. E. Bottazzi, E. Hossain, Z. Liu, K. M. Jones, L.-I. McCall

This study examines metabolomic changes in the heart during chronic T. cruzi infection, linking metabolic alterations to cardiac fibrosis and inflammation.

bioRxiv · Sep 17, 2020Microbiology

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

W.-H. Chen, X. Tao, A. Agrawal, A. Algaissi, B.-H. Peng, J. Pollet, U. Strych, M. E. Bottazzi, P. J. Hotez, S. Lustigman, L. Du, S. Jiang, C.-T. K. Tseng

This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.

bioRxiv · May 15, 2020Immunology