Author

U. Strych

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 6

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Assay:proteomics· 5 Organism:mouse· 4 Research Focus:drug response / drug discovery· 3 Research Focus:host-pathogen & immune response· 3 Organism:human· 1 Assay:protein sequence· 1 Organism:yeast· 1

Frequent Co-Authors

M. E. Bottazzi· 5 shared P. J. Hotez· 5 shared W.-H. Chen· 5 shared Z. Liu· 4 shared B. Zhan· 3 shared J. Altieri Rivera· 3 shared J. Lee· 3 shared J. Pollet· 3 shared

Activity by Year

2020-2022 · peak 4/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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5 shared papersImmunology

M. E. Bottazzi

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6 papers

Recent·Most cited

CspZ FH-binding sites as epitopes promote antibody-mediated Lyme borreliae clearance

Y.-L. Chen, A. L. Marcinkiewicz, T. A. Nowak, R. T. Kundu, Z. Liu, U. Strych, M.-E. Bottazzi, W.-H. Chen, Y.-P. Lin

The paper shows that antibodies targeting CspZ FH-binding sites effectively clear Lyme borreliae in vitro and in vivo, highlighting their importance for vaccine development.

bioRxiv · May 24, 2022Immunology

Alum:CpG adjuvant enables SARS-CoV-2 RBD-induced protection in aged mice and synergistic activation of human elder type 1 immunity

E. Nanishi, F. Borriello, T. R. O'Meara, M. E. McGrath, Y. Saito, R. E. Haupt, H.-S. Seo, S. D. van Haren, B. Brook, J. Chen, J. Diray-Arce, S. Doss-Gollin, M. De Leon, K. Chew, M. Menon, , D. J. Dowling

This study evaluates AH:CpG adjuvant's ability to enhance RBD vaccine efficacy in aged mice and human elder cells, showing strong neutralizing antibody responses and cytokine production.

bioRxiv · May 20, 2021Immunology

Process Development and Scale-up Optimization of the SARS-CoV-2 Receptor Binding Domain-Based Vaccine Candidate, RBD219-N1C1

J. Lee, Z. Liu, W.-H. Chen, J. Wei, R. Kundu, R. Adhikari, J. Altieri Rivera, P. M. Gillespie, U. Strych, B. Zhan, P. J. Hotez, M. E. Bottazzi

The paper optimizes the production process for a SARS-CoV-2 vaccine candidate, achieving high yield and purity through yeast fermentation and chromatographic purification.

bioRxiv · Dec 30, 2020Immunology

Genetic Modification to Design a Stable Yeast-expressed Recombinant SARS-CoV-2 Receptor Binding Domain as a COVID-19 Vaccine Candidate

W.-H. Chen, J. Wei, R. T. Kundu, R. Adhikari, Z. Liu, J. Lee, L. Versteeg, C. Poveda, B. Keegan, M. J. Villar, A. C. de Araujo Leao, J. Altieri Rivera, P. M. Gillespie, J. Pollet, U. Strych, , M. E. Bottazzi

The paper genetically modifies SARS-CoV-2 RBD variants in yeast to identify a more stable and manufacturable vaccine candidate.

bioRxiv · Nov 9, 2020Immunology

SARS-CoV-2 RBD219-N1C1: A Yeast-Expressed SARS-CoV-2 Recombinant Receptor-Binding Domain Candidate Vaccine Stimulates Virus Neutralizing Antibodies and T-cell Immunity in Mice

J. Pollet, W.-H. Chen, L. Versteeg, B. Keegan, B. Zhan, J. Wei, Z. Liu, J. Lee, R. Kundu, R. Adhikari, C. Poveda, M. J. Villar Mondragon, A. C. de Araujo Leao, J. Altieri Rivera, Z. Momin, , M. E. Bottazzi

This study develops a yeast-expressed SARS-CoV-2 RBD protein vaccine candidate, RBD219-N1C1, which induces neutralizing antibodies and T-cell responses in mice.

bioRxiv · Nov 4, 2020Immunology

Yeast-Expressed SARS-CoV Recombinant Receptor-Binding Domain (RBD219-N1) Formulated with Aluminum Hydroxide Induces Protective Immunity and Reduces Immune Enhancement

W.-H. Chen, X. Tao, A. Agrawal, A. Algaissi, B.-H. Peng, J. Pollet, U. Strych, M. E. Bottazzi, P. J. Hotez, S. Lustigman, L. Du, S. Jiang, C.-T. K. Tseng

This paper develops a SARS-CoV subunit vaccine using yeast-expressed RBD219-N1 with Alhydrogel® and shows it provides full protection against SARS-CoV challenge in mice.

bioRxiv · May 15, 2020Immunology