Stefano Mattarocci

The paper identifies a threshold telomere length in telomerase-negative cells that triggers replicative senescence and genomic instability through dysfunction of the shortest telomere.

This study presents cryo-EM structures of yeast NHEJ complexes, revealing mechanisms for DNA-end protection and ligation without DNA-PKcs.

This paper reviews the role of Rad5 in telomere replication and its connection to the DNA Damage Tolerance pathway in yeast.

The paper reveals that Rap1 inhibits Ku's NHEJ function at telomeres by obstructing Ku's inward translocation, preventing promiscuous repair.

The paper shows that dense Rap1 arrays block DNA loop extrusion by condensin in yeast, acting as contact insulators and affecting dicentric chromosome resolution.

This study shows the Rad55-Rad57 complex promotes Rad51 filament stability on UV-induced single-strand DNA gaps, counteracting error-prone polymerases to favor error-free homologous recombination.

The paper addresses concerns about ChEC-seq's ability to distinguish signal from noise by demonstrating normalization methods and validating its reliability through functional assays.

The paper investigates how opposing chromatin remodelers influence transcription initiation frequency and start site selection in budding yeast by analyzing their binding and nucleosome displacement activity.

This study identifies Sfp1 as a master regulator of cell growth and division in yeast by coordinating gene expression through two distinct promoter binding modes.

The paper shows that RSC remodeler and pioneer factors work independently to position the +1 nucleosome at yeast promoters, facilitating transcription initiation through DNA sequence-directed action.