Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures
Marcella Birtele, Yogita Sharma, Petter Storm, Janko Kajtez, Jenny Nelander Wahlestedt, Edoardo Sozzi, Fredrik Nilsson, Simon Stott, Xiaoling He, Bengt Mattsson, Daniella Rylander Ottosson, Roger A. Barker, Alessandro Fiorenzano, Malin Parmar
The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.
bioRxiv · Oct 1, 2020 · PreprintNeuroscience