Daniella Rylander Ottosson

Transient matrix remodeling during direct cell-fate reprogramming enables self-assembly of dense neuronal niches

This paper describes a method to generate dense neuronal microcultures by combining fibroblast reprogramming with matrix remodeling in collagen microgels.

Long-lasting structural and functional maturation in transplanted human neurons reprogrammed from glial progenitor cells

This study shows human neurons reprogrammed from glial progenitor cells survive and mature functionally in immunodeficient mice for up to 10 months.

Injectable 3D microcultures enable intracerebral transplantation of mature neurons directly reprogrammed from patient fibroblasts

This study develops a 3D microculture method to generate mature dopamine neurons from patient fibroblasts, which can be transplanted into a Parkinson's disease rat model to form functional neuron grafts.

Efficient generation of human oligodendrocyte grafts that restore myelin in adult human brain tissue

This study develops a method to efficiently generate human oligodendrocytes from induced pluripotent stem cells, which can form functional myelinating grafts in adult human brain tissue.

Generating human parvalbumin interneurons through 3D glia reprogramming

This paper describes a method to generate human parvalbumin interneurons from glial precursor cells using direct reprogramming and identifies a distinct transcriptional profile and reprogramming trajectory.

Label-free high-resolution infrared spectroscopy for spatiotemporal analysis of complex living systems

This paper demonstrates the use of O-PTIR for fast, non-destructive spatiotemporal chemical analysis of unprocessed biopsies, living brain tissue, and vertebrates.

Single cell transcriptional and functional analysis of human dopamine neurons in 3D fetal ventral midbrain organoid like cultures

The paper uses single-cell RNA sequencing to profile fetal human midbrain dopamine neurons at different developmental stages and establishes a 3D culture system to study their functional maturation.