This study identifies SON as a critical factor for splicing GC-rich genes, showing its role in stabilizing weak splice sites and enhancing gene expression efficiency.

bioRxiv · Mar 24, 2026 · PreprintMolecular Biology

ZBP1 Senses Splicing Aberration through Z-RNA to promote Cell Death

Zhang-Hua Yang, Puqi Wu, Bo-Xin Zhang, Congrong Yang, Jia Huang, Lei Wu, Shaoyu Guo, Yuenan Zhou, Yuanhui Mao, Yafei Yin, Xiurong Wu, Pu Cheng, Baizhou Li, Rongbin Zhou, Han‐Ming Shen, , Wei Mo

This study shows that spliceosome inhibition generates Z-RNA, sensed by ZBP1 to trigger necroptosis in response to splicing aberrations.

Molecular Cell · Apr 22, 2025Peer-reviewedCell Biology

U1 snRNP regulates chromatin retention of noncoding RNAs

Yafei Yin, Jiayun Lu, Xuechun Zhang, Wen Shao, Yanhui Xu, Pan Li, Yantao Hong, Li Cui, Ge Shan, Bin Tian, Qiangfeng Cliff Zhang, Xiaohua Shen

The paper identifies a U1 snRNP recognition motif that regulates chromatin retention of noncoding RNAs through experimental and computational methods.

Nature · Mar 11, 2020Peer-reviewedMolecular Biology

L1 and B1 repeats blueprint the spatial organization of chromatin

J. Yuyang Lu, Lei Chang, Tong Li, Ting Wang, Yafei Yin, Ge Zhan, Ke Zhang, Michelle Percharde, Liang Wang, Qi Peng, Pixi Yan, Hui Zhang, Xue Han, Xianju Bi, Wen Shao, , Xiaohua Shen

This study identifies L1 and B1 retrotransposons as key elements shaping the 3D chromatin structure through spatial compartmentalization in human and mouse cells.

bioRxiv · Oct 13, 2019 · PreprintGenomics