Author

Boris Macek

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:drug response / drug discovery· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Alexander N.R. WeberiD· 1 shared Andrea A. GustiD· 1 shared Anurag Singh· 1 shared Carly Dillen· 1 shared Carol V. RobinsoniD· 1 shared Cécile Gouttefangeas· 1 shared Charles S. Dela CruziD· 1 shared Christoph Täumer· 1 shared

Activity by Year

2018-2018 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Alexander N.R. WeberORCID

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2 papers

Recent·Most cited

The fungal ligand chitin directly binds and signals inflammation dependent on oligomer size and TLR2

Katharina Fuchs, Yamel Cardona Gloria, Olaf-Oliver Wolz, Franziska Herster, Lokesh Sharma, Carly Dillen, Christoph Täumer, Sabine Dickhöfer, Zsofia Bittner, Truong-Minh Dang, Anurag Singh, Daniel Haischer, Maria A. Schlöffel, Kirsten J. Koymans, Tharmila Sanmuganantham, , Alexander N.R. Weber

This study identifies chitin oligomers as the smallest immunologically active motif and TLR2 as the primary receptor for chitin, showing size-dependent signaling and therapeutic potential.

bioRxiv · Mar 5, 2018 · PreprintImmunology

Structure of the Core of the Type Three Secretion System ExportApparatus

Lucas Kuhlen, Patrizia Abrusci, Steven Johnson, Joseph Gault, Justin Deme, Joseph Caesar, Tobias Dietsche, Mehari Tesfazgi Mebrhatu, Tariq Ganief, Boris Macek, Samuel Wagner, Carol V. Robinson, Susan M. Lea

The paper determines the structure of the T3SS export gate core using cryo-EM, revealing a helical assembly with 5:4:1 stoichiometry and identifying it as a key component of the secretion channel.

bioRxiv · Jan 17, 2018 · PreprintMicrobiology