Author

Maria L. Sapar

New York Stem Cell Foundation

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2 Cancer Biology· 1 Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cell type annotation· 3 Organism:human· 3 Organism:Drosophila· 2 Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:database / resource· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Bei WangiD· 2 shared Chun HaniD· 2 shared Daniel J PaulliD· 2 shared Dorota N. Moroziewicz· 2 shared Frederick J. MonsmaiD· 2 shared Hui JiiD· 2 shared Tomasz Rusielewicz· 2 shared Amy R. PoeiD· 1 shared

Activity by Year

2018-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersNeuroscience

Bei WangORCID

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Author profile →

5 papers

Recent·Most cited

A patient-derived ovarian cancer organoid platform to study susceptibility to natural killer cells

Marisa Mercadante, Armin Scheben, Jacob Estrada, Jan Savas-Carstens, William Sullivan, Nicholas Housel, Maria L. Sapar, Tatiana Volpari, Jax Hebner, Tomasz Rusielewicz, Frederick J. Monsma, Stefan Semrau, Yinan Wang, Laura A. Martin

The paper develops a live cell imaging assay using patient-derived ovarian cancer organoids to study natural killer cell-mediated apoptosis and identifies resistant organoid populations.

npj Precision Oncology · Dec 26, 2025Peer-reviewedCancer Biology

A repository of Ogden syndrome (NAA10) and NAA15 patient derived iPSC lines and isogenic pairs by X-chromosome screening and genome-editing.

Josephine Wesely, Tom Rusielewicz, Yu-Ren Chen, Brigham J. Hartley, Dayna McKenzie, Matthew Yim, Colin T. Maguire, Ryan D. Bia, Sarah Franklin, Rikhil Makwana, Elaine J. Marchi, Manali Nikte, Soha Patil, Maria L. Sapar, Dorota N. Moroziewicz, , Gholson J. Lyon

The paper describes the generation and characterization of patient-derived iPSC lines and isogenic pairs for Ogden syndrome, including CRISPR corrections and X-chromosome screening.

bioRxiv · Sep 28, 2024 · PreprintGenetics

Patient iPSC models reveal glia-intrinsic phenotypes in multiple sclerosis

Benjamin L.L. Clayton, Lilianne Barbar, Maria L. Sapar, Kriti Kalpana, Chandrika Rao, Bianca Migliori, Tomasz Rusielewicz, Daniel J Paull, Katie Brenner, Dorota N. Moroziewicz, Ilana Katz Sand, Patrizia Casaccia, Paul J. Tesar, Valentina Fossati

The paper uses iPSC-derived glia cultures from MS patients to identify glia-intrinsic disease mechanisms and potential therapeutic targets.

Cell stem cell · Aug 25, 2024Peer-reviewedNeuroscience

The Drosophila chemokine-like Orion bridges phosphatidylserine and Draper in phagocytosis of neurons

Hui Ji, Bei Wang, Yifan Shen, David Labib, Joyce Lei, Xinchen Chen, Maria L. Sapar, Ana Boulanger, Jean‐Maurice Dura, Chun Han

This study identifies Orion as a bridging molecule that connects phosphatidylserine and Draper in Drosophila phagocytosis of degenerating neurons, revealing a conserved mechanism.

Proceedings of the National Academy of Sciences · Jun 5, 2023Peer-reviewedNeuroscience

Highly efficient CRISPR/Cas9-mediated tissue specific mutagenesis in Drosophila

Amy R. Poe, Bei Wang, Maria L. Sapar, Hui Ji, Kailyn Li, Tireniolu Onabajo, Rushaniya Fazliyeva, Mary Gibbs, Yue Qiu, Yuzhao Hu, Chun Han

This paper introduces CRISPR-TRiM, a method for tissue-specific gene knockout in Drosophila, showing it can reveal redundant gene functions in neuronal development.

bioRxiv · Feb 20, 2018 · PreprintDevelopmental Biology