Sonia Lameiras

The paper shows EWSR1::FLI1 fusion drives the production of cancer-specific neoproteins in Ewing sarcoma, revealing a reversible dark proteome with therapeutic potential.

This study identifies six distinct intestinal fibroblast subpopulations in mice using scRNA-seq, maps their spatial distribution, and proposes a standardized nomenclature for improved classification and functional understanding.

The paper identifies a common origin for effector and regulatory CD4+ T cells in non-small cell lung cancer through single-cell analysis, revealing their plasticity and role in immune responses.

This study shows CCG interruptions in DM1 are unstable and hypermethylated, contributing to CTG repeat stabilization.

The paper identifies microproteins encoded by intronic polyadenylation isoforms in the 5' part of genes and shows their role in modulating cisplatin response in cancer cells.

The paper uses single-cell RNA sequencing to show that the mouse pelvic ganglion contains neurons distinct from both sympathetic and parasympathetic types, and that pelvic organs are innervated by a divergent sympathetic pathway, not parasympathetic or typical sympathetic neurons.

This study uses TALENs to contract CTG repeats in DM1 cells, achieving 68% contraction with a recoded TALEN, while SaCas9 failed, and identifies potential off-target effects.

This study shows that DNMT3A-dependent DNA methylation is essential for spermatogonial stem cells to commit to differentiation and spermatogenesis.

The paper identifies somatic transposition in Drosophila intestine, showing it occurs in active chromatin and is linked to tumor suppressor gene inactivation.