Author

R. Wechsler-Reya

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Research Focus:cancer & tumor microenvironment· 3 Organism:mouse· 3 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Assay:ChIP-seq· 1 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

A. Bagchi· 1 shared A. C. Resnick· 1 shared A. Deshpande· 1 shared A. Rosa Campos· 1 shared A. Stern· 1 shared B. Chen· 1 shared C. A. Koch· 1 shared C. Brimley· 1 shared

Activity by Year

2019-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 12 mutual co-author links

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1 shared paperCancer Biology

A. Bagchi

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4 papers

Recent·Most cited

Thyroid Hormone Suppresses Medulloblastoma Progression Through Promoting Terminal Differentiation of Tumor Cells

Z. Yang, Y. Yang, S. A. Valdes-Rives, Q. Liu, Y. Li, J. Tan, Y. Tan, C. A. Koch, Y. Rong, S. R. Houser, S. Wei, K. Cai, S.-y. Cheng, T. Curran, R. Wechsler-Reya

This study shows thyroid hormone promotes differentiation of medulloblastoma cells, reducing tumor growth by reversing EZH2-mediated repression of NeuroD1.

bioRxiv · Feb 13, 2024Cancer Biology

Development of GPC2-directed chimeric antigen receptors using mRNA for pediatric brain tumors

J. B. Foster, C. Griffin, J. L. Rokita, A. Stern, C. Brimley, K. Rathi, M. V. Lane, S. N. Buongervino, T. Smith, P. J. Madsen, D. Martinez, R. Wechsler-Reya, K. Kariko, P. B. Storm, D. M. Barrett, , K. R. Bosse

This study develops mRNA chimeric antigen receptor T cells targeting GPC2 on pediatric brain tumors, showing significant tumor regression and prolonged survival without toxicity.

bioRxiv · Jul 6, 2021Cancer Biology

A JAK/STAT-Mediated Inflammatory Signaling Cascade Drives Oncogenesis In AF10-Rearranged AML

B. Chen, A. Deshpande, K. O. Barbosa, M. Kleppe, X. Lei, N. Yeddula, A. Rosa Campos, R. Wechsler-Reya, A. Bagchi, S. Meshinchi, C. J. Eaves, I. Jeremias, T. Haferlach, D. Frank, Z. Ronai, , A. Deshpande

This study identifies JAK1 as a therapeutic target in AF10-rearranged AML by showing its role in JAK/STAT-mediated inflammatory signaling and oncogenesis.

bioRxiv · Aug 31, 2020Cancer Biology

Nilotinib, an approved leukemia drug, inhibits Smoothened signaling in Hedgehog-dependent medulloblastoma

K. K. Chahal, J. Li, I. Kufareva, M. Parle, D. D. Durden, R. Wechsler-Reya, C. C. Chen, R. Abagyan

The paper shows Nilotinib inhibits Hedgehog signaling in medulloblastoma by directly targeting Smoothened, outperforming Vismodegib in cell lines and xenograft models.

bioRxiv · Mar 25, 2019Cancer Biology