Author

C. D. Allis

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Biochemistry· 2 Microbiology· 1

Signature Assays, Organisms & Methods

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Research Focus:chromatin & epigenetic regulation· 4 Organism:mouse· 4 Assay:ChIP-seq· 3 Approach:experimental assay· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Assay:DNA methylation· 2 Approach:genetic perturbation / CRISPR· 2

Frequent Co-Authors

S. W. Lowe· 3 shared Y. M. Soto-Feliciano· 3 shared B. A. Garcia· 2 shared F. J. Sanchez-Rivera· 2 shared Y.-j. Ho· 2 shared A. A. Leal· 1 shared A. Armache· 1 shared A. Banito· 1 shared

Activity by Year

2017-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersCancer Biology

S. W. Lowe

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer

Y. M. Soto-Feliciano, C. Zhu, J. P. Morris, C.-h. Huang, R. P. Koche, Y.-j. Ho, A. Banito, C.-w. Chen, A. Shroff, S. Tian, L. Geulah, C.-c. Chen, M. Fennell, S. Armstrong, C. D. Allis, , S. W. Lowe

This study shows that MLL3 regulates the CDKN2A tumor suppressor locus in liver cancer by affecting chromatin modifications and gene expression.

bioRxiv · Jun 7, 2022Cancer Biology

A molecular switch between mammalian MLL complexes dictates response to Menin-MLL inhibition

Y. M. Soto-Feliciano, F. J. Sanchez-Rivera, F. Perner, D. W. Barrows, E. R. Kastenhuber, Y.-J. Ho, T. Carroll, Y. Xiong, D. Anand, A. Soshnev, L. Gates, M. C. Beytagh, D. Cheon, S. Gu, X. S. Liu, , C. D. Allis

The paper identifies a molecular switch between MLL1-Menin and MLL3/4-UTX complexes that determines response to Menin-MLL inhibitors in leukemia.

bioRxiv · Oct 22, 2021Cancer Biology

Stable Isotope Tracing In Vivo Reveals A Metabolic Bridge Linking The Microbiota To Host Histone Acetylation

P. J. Lund, L. A. Gates, M. Leboeuf, S. A. Smith, L. Chau, E. S. Friedman, M. Lopes, Y. Saiman, M. S. Kim, C. Petucci, C. D. Allis, G. D. Wu, B. A. Garcia

This study uses stable isotope tracing to show that gut microbiota supply carbon for host histone acetylation, linking microbial metabolism to host epigenetic regulation.

bioRxiv · Jul 5, 2021Biochemistry

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

H.- H. Hoffmann, W. M. Schneider, F. J. Sanchez-Rivera, J. M. Luna, A. W. Ashbrook, Y. M. Soto-Feliciano, A. A. Leal, J. Le Pen, I. Ricardo-Lax, E. Michailidis, Y. Hao, A. F. Stenzel, A. Peace, C. D. Allis, S. W. Lowe, , C. M. Rice

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

bioRxiv · Sep 11, 2020Microbiology

Phosphorylation of the ancestral histone variant H3.3 amplifies stimulation-induced transcription

A. Armache, S. Yang, L. E. Robbins, C. Durmaz, A. W. Daman, J. Q. Jeong, A. Martinez de Paz, A. Ravishankar, T. Arslan, S. Lin, T. Panchenko, B. A. Garcia, S. Hake, H. Li, C. D. Allis, S. Z. Josefowicz

The paper identifies phosphorylation of H3.3S31 in response to pathogen sensing in macrophages and shows its role in recruiting SETD2 to enhance transcription of inflammatory genes.

bioRxiv · Oct 17, 2019 · PreprintBiochemistry

ATRX, DAXX or MEN1 mutant pancreatic neuroendocrine tumors are a distinct alpha-cell signature subgroup

C. Chan, S. Laddha, P. Lewis, M. Koletsky, K. Robzyk, E. Da Silva, P. Torres, B. Untch, P. Bose, T. Chan, D. Klimstra, C. D. Allis, L. Tang

bioRxiv · Sep 28, 2017Cancer Biology