W. M. Schneider

A genome-wide arrayed CRISPR screen identifies PLSCR1 as an intrinsic barrier to SARS-CoV-2 entry that recent virus variants have evolved to resist

The paper identifies PLSCR1 as a host factor restricting SARS-CoV-2 entry, which recent variants have evolved to bypass, through a CRISPR screen and integration of genetic studies.

Antiviral DExD/H-box helicase 60 selectively inhibits translation from type II internal ribosome entry sites

This study shows that DDX60 selectively inhibits translation from type II viral IRESs, reducing replication of EMCV and FMDV but not type I IRES viruses.

Human hepatocyte PNPLA3 148M exacerbates rapid non-alcoholic steatohepatitis development in chimeric mice

This study shows that the PNPLA3 148M variant in human hepatocytes worsens non-alcoholic steatohepatitis in chimeric mice on a hypercaloric diet.

Genome-scale identification of SARS-CoV-2 and pan-coronavirus host factor networks

The paper identifies host factors required for SARS-CoV-2 and three seasonal coronaviruses using CRISPR screens, revealing shared and virus-specific dependencies.

Functional interrogation of a SARS-CoV-2 host protein interactome identifies unique and shared coronavirus host factors

The paper identifies host factors critical for SARS-CoV-2 and related coronaviruses using CRISPR screens, revealing both shared and unique factors across different viruses and temperatures.

Public broadly neutralizing antibodies against hepatitis B virus in individuals with elite serologic activity

The paper identifies broadly neutralizing antibodies against HBV in elite neutralizers and shows that combinations of bNAbs targeting different epitopes are more effective than single bNAbs.

An RNA-based system to study hepatitis B virus replication and select drug-resistance mutations

This paper describes an RNA-based system to study HBV replication and predict drug resistance mutations.