Phase separation induced by cohesin SMC protein complexes
J.-K. Ryu, C. Bouchoux, H. W. Liu…·C. Dekker
Yeast cohesin phase separates with DNA into liquid droplets via ATP-independent DNA bridging.
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45 papers
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J.-K. Ryu, C. Bouchoux, H. W. Liu…·C. Dekker
Yeast cohesin phase separates with DNA into liquid droplets via ATP-independent DNA bridging.
F. Brauns, G. Pawlik, J. Halatek…·C. Dekker
This study reconciles differences in Min-protein pattern formation between in vitro and in vivo settings by showing how bulk-surface coupling influences dynamics.
J.-K. Ryu, A. J. Katan, E. O. van der Sluis…·C. Dekker
The paper uses AFM to visualize yeast condensin and its DNA interactions, suggesting a scrunching model for DNA loop extrusion.
A. Fragasso, S. Schmid, C. Dekker
The paper compares noise characteristics in biological and solid-state nanopores, finding that SiNx solid-state nanopores offer the highest signal-to-noise ratio, with controlled slowdowns significantly enhancing SNR.
E. Kim, J. W. J. Kerssemakers, I. A. Shaltiel…·C. Dekker
This study shows yeast condensin complexes can traverse each other to form Z-loops, enabling dynamic DNA packaging and compaction through various looping structures.
M. Le Gars, C. Seiler, A. Kay…·C. Blish
This study identifies CD38 as a key receptor in human NK cells that facilitates immune synapse formation, enhancing antiviral and antitumor responses.
M. Schaich, J. Cama, K. Al Nahas…·U. F. Keyser
The paper develops a microfluidic platform to measure drug permeability across biomimetic liposome membranes, demonstrating improved control and yield compared to existing methods.
F. Hol, G. M. Whitesides, C. Dekker
The paper introduces a low-cost, equipment-free platform using paper scaffolds to study bacterial colonization dynamics and community composition in structured habitats.
A. J. Perez, Y. Cesbron, S. L. Shaw…·M. E. Winkler
This paper investigates FtsZ dynamics and its relationship to septal PG synthesis in Streptococcus pneumoniae, finding that FtsZ movement is continuous and independent of PG synthesis rate.
F. Wu, P. Swain, L. Kuijpers…·C. Dekker
This study shows that spatial confinement in E. coli determines chromosome size and position, with simulations supporting depletion effects from cytosolic crowders.
S. H. Kim, M. Ganji, J. v. d. Torre…·C. Dekker
The paper shows DNA sequence encodes supercoil positions by pinning plectonemes, with intrinsic curvature over ~70 bp being key, and predicts plectonemes upstream of prokaryotic transcription start sites.
J. M. Eeftens, S. Bisht, J. Kerssemakers…·C. Dekker
This study uses single-molecule magnetic tweezers to show condensin compacts DNA in large steps, requiring ATP hydrolysis for stable binding and compaction.
T. Terekawa, S. Bisht, J. Eeftens…·E. Greene
The paper uses single-molecule imaging to show that yeast condensin is an ATP-dependent DNA translocating motor complex with high processivity and specific translocation mechanism.