Author

H. R. Keys

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:genetic perturbation / CRISPR· 3 Organism:human· 3 Research Focus:cancer & tumor microenvironment· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 1 Organism:mouse· 1

Frequent Co-Authors

D. M. Sabatini· 2 shared A. Detappe· 1 shared A. Letai· 1 shared A. Tsherniak· 1 shared B. Moodie· 1 shared C. H. Adelmann· 1 shared C. N. Cunningham· 1 shared C. S. Goul· 1 shared

Activity by Year

2018-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 11 mutual co-author links

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2 shared papersCancer Biology

D. M. Sabatini

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Author profile →

4 papers

Recent·Most cited

Functional genetics reveals modulators of anti-microtubule drug sensitivity

K.-C. Su, E. Radul, N. K. Maier, M.-J. Tsang, C. S. Goul, B. Moodie, H. R. Keys, I. M. Cheeseman

The paper identifies gene targets that modulate sensitivity to anti-microtubule drugs using CRISPR screens in human cells.

bioRxiv · Mar 12, 2024Cell Biology

Co-deletion of ATAD1 with PTEN primes cells for BIM-mediated apoptosis

J. M. Winter, H. L. Fresenius, H. R. Keys, C. N. Cunningham, J. Ryan, D. Sirohi, J. A. Berg, S. R. Tripp, P. Barta, N. Agarwal, A. Letai, D. M. Sabatini, M. L. Wohlever, J. Rutter

The paper shows that co-deletion of ATAD1 with PTEN makes cancer cells more susceptible to apoptosis via BIM activation, correlating with better patient survival.

bioRxiv · Jul 1, 2021 · PreprintCancer Biology

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

N. J. Rossiter, K. S. Huggler, C. H. Adelmann, H. R. Keys, R. W. Soens, D. M. Sabatini, J. R. Cantor

This study uses CRISPR screens in different media to identify conditionally essential genes in human cells, showing how medium composition affects gene essentiality.

bioRxiv · Aug 31, 2020Cancer Biology

Inhibition of mitochondrial ferredoxin 1 (FDX1) prevents adaptation to proteotoxic stress

P. Tsvetkov, A. Detappe, K. Cai, H. R. Keys, Z. Brune, W. Ying, P. Thiru, M. Reidy, G. Kugener, A. Tsherniak, S. Santagata, L. Whitesell, J. L. Markley, I. M. Ghobrial, S. Lindquist

This study identifies FDX1 inhibition as a strategy to prevent proteasome inhibitor resistance in cancer by targeting mitochondrial Fe-S cluster biosynthesis.

bioRxiv · Mar 24, 2018Cancer Biology