Author

J. R. Cantor

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Cell Biology· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:experimental assay· 3 Assay:bulk RNA-seq· 2 Research Focus:cancer & tumor microenvironment· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:drug response / drug discovery· 2 Approach:genetic perturbation / CRISPR· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

K. S. Huggler· 2 shared N. J. Rossiter· 2 shared A. Devlieger· 1 shared A. Dillin· 1 shared A. E. Lefebvre· 1 shared A. L. Hunger· 1 shared A. Richards· 1 shared C. Bertozzi· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 15 mutual co-author links

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2 shared papersImmunology

K. S. Huggler

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

The microenvironment dictates glycocalyx construction and immune surveillance

K. Tharp, S. Park, G. A. Timblin, A. Richards, J. Berg, N. Twells, N. M. Riley, E. Peltan, D. J. Shon, E. Stevenson, C. K. Tsui, F. Palomba, A. E. Lefebvre, R. Soens, N. Ayad, , V. Weaver

This study shows that the physical properties of the microenvironment influence glycocalyx composition and immune surveillance in vitro using physiologically relevant models.

bioRxiv · Jun 23, 2023 · PreprintCell Biology

Conditional lethality profiling reveals anticancer mechanisms of action and drug-nutrient interactions

K. M. Flickinger, K. M. Wilson, N. J. Rossiter, A. L. Hunger, T. D. Lee, M. D. Hall, J. R. Cantor

This study uses conditional lethality profiling in human plasma-like medium to identify drug mechanisms and interactions with nutrients, revealing new therapeutic strategies.

bioRxiv · Jun 4, 2023Cancer Biology

Clinically-relevant T cell expansion protocols activate distinct cellular metabolic programs and phenotypes

S. MacPherson, S. Keyes, M. K. Kilgour, J. Smazynski, J. Sudderth, T. Turcotte, A. Devlieger, J. Yu, K. S. Huggler, J. R. Cantor, R. J. DeBerardinis, C. Siatskas, J. J. Lum

The paper compares five T cell expansion protocols and finds they induce distinct metabolic programs and phenotypes, with some conditions impairing T cell function despite metabolic adaptation.

bioRxiv · Aug 24, 2021Immunology

CRISPR screens in physiologic medium reveal conditionally essential genes in human cells

N. J. Rossiter, K. S. Huggler, C. H. Adelmann, H. R. Keys, R. W. Soens, D. M. Sabatini, J. R. Cantor

This study uses CRISPR screens in different media to identify conditionally essential genes in human cells, showing how medium composition affects gene essentiality.

bioRxiv · Aug 31, 2020Cancer Biology