Author

C. J. Childs

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Bioengineering· 1 Cell Biology· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:human· 3 Research Focus:development & morphogenesis· 2 Assay:organoid / primary culture· 2 Research Focus:drug response / drug discovery· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

J. R. Spence· 3 shared C. Loebel· 2 shared M. K. Eiken· 2 shared S. Huang· 2 shared A. S. Conchola· 1 shared A. Singh· 1 shared A. Vallie· 1 shared A. Wu· 1 shared

Activity by Year

2021-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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3 shared papersCell Biology

J. R. Spence

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Author profile →

3 papers

Recent·Most cited

Nascent matrix deposition supports alveolar organoid formation from aggregates in synthetic hydrogels

M. K. Eiken, C. J. Childs, L. K. Brastrom, T. Frum, E. M. Plaster, O. Shachaf, S. Pfeiffer, J. E. Levine, K. Alysandratos, D. N. Kotton, J. R. Spence, C. Loebel

This study develops a Matrigel-free method using synthetic hydrogels to form alveolar organoids, showing they secrete their own extracellular matrix for growth.

bioRxiv · Mar 19, 2024Cell Biology

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

C. J. Childs, H. M. Poling, K. Chen, Y.-H. Tsai, A. Wu, C. W. Sweet, A. Vallie, M. K. Eiken, S. Huang, R. Schreiner, Z. Xiao, A. S. Conchola, M. F. Anderman, E. M. Holloway, A. Singh, , J. R. Spence

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

bioRxiv · Nov 6, 2023 · PreprintBioengineering

A Human Liver Organoid Screening Platform for DILI Risk Prediction

C. J. Zhang, S. R. Meyer, M. J. O'Meara, S. Huang, M. M. Capeling, D. Ferrer-Torres, C. J. Childs, J. R. Spence, R. J. Fontana, J. Z. Sexton

This study evaluates human liver organoids for DILI risk prediction using high-throughput screening and a liver-on-chip system, showing enhanced predictive capacity and physiological relevance.

bioRxiv · Aug 26, 2021Pharmacology & Toxicology