Author

Y.-H. Tsai

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 4 Bioengineering· 2 Biochemistry· 1 Biophysics· 1 Cell Biology· 1 Immunology· 1

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Approach:experimental assay· 11 Organism:human· 7 Research Focus:cell type annotation· 4 Organism:mouse· 4 Assay:bulk RNA-seq· 3 Research Focus:development & morphogenesis· 3 Assay:ChIP-seq· 2 Research Focus:chromatin & epigenetic regulation· 2

Frequent Co-Authors

J. R. Spence· 3 shared W. Gong· 3 shared A. Storey· 2 shared A. Tackett· 2 shared A. Wu· 2 shared E. M. Holloway· 2 shared G. G. Wang· 2 shared J. Giudice· 2 shared

Activity by Year

2018-2025 · peak 6/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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3 shared papersBioengineering

J. R. Spence

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Author profile →

12 papers

Recent·Most cited

Activation of Store-Operated Calcium Entry and Mitochondiral Respiration by Enterovirus 71 Is Essential for Efficient Virus Replication

B.-Y. Hsu, Y.-H. Tsai, T.-C. Weng, S.-H. Kung

This paper shows that EV71 infection triggers store-operated Ca2+ entry and mitochondrial respiration, which are essential for virus replication and release.

mBio · Aug 13, 2025Peer-reviewedMicrobiology

Coordinated differentiation of human intestinal organoids with functional enteric neurons and vasculature

C. J. Childs, H. M. Poling, K. Chen, Y.-H. Tsai, A. Wu, C. W. Sweet, A. Vallie, M. K. Eiken, S. Huang, R. Schreiner, Z. Xiao, A. S. Conchola, M. F. Anderman, E. M. Holloway, A. Singh, , J. R. Spence

This study develops an in vitro method to generate human intestinal organoids containing multiple cell types, including neurons, endothelial cells, and smooth muscle, which functionally mimic gut physiology.

bioRxiv · Nov 6, 2023 · PreprintBioengineering

Enhanced expression of 4-Cl-IAA and 6-Cl-IAA by touch stimulus for rapid and differential growths of the Madeira vine

M.-H. Ma, E. Batsaikhan, C.-M. Wu, H.-H. Lee, C.-I. Luo, N.-J. Chen, J.-D. Chung, C.-T. Chien, Y.-H. Tsai, W.-H. Li

This study shows that touch stimulus increases 4-Cl-IAA and 6-Cl-IAA expression in Madeira vine, leading to differential growth responses.

bioRxiv · Apr 13, 2022 · PreprintPlant Biology

In vitro models of the human esophagus reveal ancestrally diverse response to injury

D. Ferrer-Torres, J. H. Wu, C. J. Zhang, M. A. Hammer, M. K. Dame, A. Wu, E. M. Holloway, K. Karpoff, C. L. McCarthy, M. S. Bohm, S. Huang, Y.-H. Tsai, S. P. Hogan, D. K. Turgeon, J. Lin, , J. R. Spence

The paper develops an in vitro model of the human esophagus to study ancestral differences in response to bile acid injury, finding significant differences between European American and African American-derived cells.

bioRxiv · May 20, 2021 · PreprintCell Biology

A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing

H. Fan, Y. Guo, Y.-H. Tsai, A. Storey, A. Kim, W. Gong, R. Edmondson, S. Mackintosh, H. Li, S. Byrum, A. Tackett, L. Cai, G. G. Wang

This paper identifies a conserved BAH module in BAHD1 that reads H3K27me3 and mediates gene silencing by recruiting histone deacetylases, essential for development.

bioRxiv · Mar 11, 2021Biochemistry

Bacterial inhibition of CD8+ T-cells mediated cell death promotes neuroinvasion and within-host persistence

C. Maudet, M. Kheloufi, S. Levallois, J. Gaillard, L. Huang, C. Gaultier, Y.-H. Tsai, O. Disson, M. Lecuit

This study identifies how Listeria monocytogenes uses InlB to protect infected monocytes from CD8+ T-cell mediated death, facilitating neuroinvasion and persistence.

bioRxiv · Nov 20, 2020Immunology

Two-photon microscopy at >500 volumes/second

Y.-H. Tsai, C.-W. Liu, W.-K. Lin, C.-S. Wang, C.-H. Chiang, V. R. Singh, P. T. C. So, C.-F. Chou, S.-W. Chu

This paper introduces a high-speed two-photon microscopy system achieving over 500 volumes per second.

bioRxiv · Oct 21, 2020 · PreprintBiophysics

Dual GRIN lens two-photon endoscopy for high-speed volumetric and deep brain imaging

Y.-F. Chien, J.-Y. Lin, P.-T. Yeh, K.-J. Hsu, Y.-H. Tsai, S.-K. Chen, S.-W. Chu

This paper introduces a dual GRIN lens two-photon endoscopy technique to enhance deep-brain imaging speed and penetration depth, enabling sub-cellular and sub-second resolution of calcium dynamics.

bioRxiv · Sep 19, 2020Bioengineering

YY1 cistrome analysis uncovers an essential requirement of the YY1:BRD4-PFKP regulatory axis for promoting tumorigenesis of castration-resistant prostate cancer

L. Cai, C. Xu, Y.-H. Tsai, P. Galbo, W. Gong, A. Storey, Y. Xu, S. Byrum, Y. Whang, J. Parker, S. Mackintosh, R. Edmondson, A. Tackett, J. Huang, D. Zheng, , G. G. Wang

This study identifies a YY1:BRD4-PFKP regulatory axis critical for castration-resistant prostate cancer tumorigenesis through cistrome analysis and functional experiments.

bioRxiv · Sep 17, 2020 · PreprintCancer Biology

Snord67 promotes lymph node metastasis and regulates U6-mediated alternative splicing in breast cancer

Y. L. Chao, Y. Zhu, H. J. Wiedner, Y.-H. Tsai, L. Wilkinson, A. Porrello, A. E. D. Van Swearingen, L. A. Carey, J. Giudice, C. L. Holley, C. V. Pecot

This study identifies Snord67 as a regulator of lymph node metastasis in breast cancer by modulating U6-mediated alternative splicing.

bioRxiv · Aug 28, 2020 · PreprintCancer Biology

CRTC1-MAML2 Establishes a PGC1α-IGF1 Circuit that Confers Vulnerability to PPARγ Inhibition

A. M. Musicant, K. Parag-Sharma, W. Gong, M. Sengupta, A. Chatterjee, E. C. Henry, Y.-H. Tsai, M. Hayward, S. Sheth, R. Betancourt, T. Hackman, R. J. Padilla, J. S. Parker, J. Giudice, C. A. Flaveny, , A. L. Amelio

This study identifies a CRTC1-MAML2-driven transcriptional circuit involving PGC-14 and IGF-1 that makes mucoepidermoid carcinoma cells vulnerable to PPARγ inhibition.

bioRxiv · Jun 3, 2020 · PreprintCancer Biology

Identification, Isolation, and Characterization of Human LGR5-positive Colon Adenoma Cells

M. K. Dame, D. Attili, S. D. McClintock, P. H. Dedhia, P. Ouilette, O. Hardt, A. M. Chin, X. Xue, J. Laliberte, E. L. Katz, G. M. Newsome, D. Hill, A. Miller, Y.-H. Tsai, D. Agorku, , J. A. Colacino

The paper isolates and characterizes LGR5-positive cells from human colon adenomas using organoids and RNA-sequencing, identifying correlations with CRC-specific genes.

Development · Mar 14, 2018Peer-reviewedCancer Biology