C. J. Zhang

A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver Organoids

This paper introduces a high-throughput microfluidic liver chip system using human liver organoids to model drug-induced liver injury with improved sensitivity and prolonged drug exposure capabilities.

Screening in serum-derived medium reveals differential response to compounds targeting metabolism

The paper screens compounds targeting metabolism in serum-derived medium to identify differential responses in cancer cells, aiming to improve drug response prediction.

In Vitro Evaluation and Mitigation of Niclosamide's Liabilities as a COVID-19 Treatment.

This study evaluates niclosamide's limitations as a COVID-19 treatment and identifies analogs with improved potency and reduced toxicity.

A Human Liver Organoid Screening Platform for DILI Risk Prediction

This study evaluates human liver organoids for DILI risk prediction using high-throughput screening and a liver-on-chip system, showing enhanced predictive capacity and physiological relevance.

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

In vitro models of the human esophagus reveal ancestrally diverse response to injury

The paper develops an in vitro model of the human esophagus to study ancestral differences in response to bile acid injury, finding significant differences between European American and African American-derived cells.