J. Z. Sexton

Type I interferon governs immunometabolic checkpoints that coordinate inflammation during Staphylococcal infection

This paper shows type I interferon coordinates immunometabolic checkpoints during Staphylococcal infection by regulating metabolic and inflammatory programs in macrophages.

A High-Throughput Microphysiological Liver Chip System to Model Direct and Idiosyncratic Drug-Induced Liver Injury Using Human Liver Organoids

This paper introduces a high-throughput microfluidic liver chip system using human liver organoids to model drug-induced liver injury with improved sensitivity and prolonged drug exposure capabilities.

Imaging-based screening identifies modulators of the eIF3 translation initiation factor complex in Candida albicans

The paper uses imaging-based screening to identify compounds that inhibit hyphal transition in C. albicans, identifying eIF3 as a target of NSC 697923.

High-Content Screening to Identify Inhibitors of Dengue Virus Replication

This study identifies four nanomolar inhibitors of Dengue Virus replication using high-content screening and a viral pseudotime model.

Assessing the performance of the Cell Painting assay across different imaging systems

The paper evaluates Cell Painting assay performance across different imaging systems, finding compatibility and identifying optimal settings for each.

In Vitro Evaluation and Mitigation of Niclosamide's Liabilities as a COVID-19 Treatment.

This study evaluates niclosamide's limitations as a COVID-19 treatment and identifies analogs with improved potency and reduced toxicity.

ARF6 is a host factor for SARS-CoV-2 infection in vitro

This study identifies ARF6 as a host factor critical for SARS-CoV-2 entry and infection in vitro, showing its importance across different cell models.

Human norovirus efficiently replicates in differentiated 3D-human intestinal enteroids

This paper develops a simplified protocol for infecting 3D-human intestinal enteroids with human norovirus, showing improved infection efficiency and host response analysis.

A Human Liver Organoid Screening Platform for DILI Risk Prediction

This study evaluates human liver organoids for DILI risk prediction using high-throughput screening and a liver-on-chip system, showing enhanced predictive capacity and physiological relevance.

Morphological Cell Profiling of SARS-CoV-2 Infection Identifies Drug Repurposing Candidates for COVID-19

This study identifies 17 FDA-approved compounds with antiviral efficacy against SARS-CoV-2 using high-throughput screening and finds lactoferrin as a promising drug candidate with multiple antiviral mechanisms.

Knockout of murine Lyplal1 confers sex-specific protection against diet-induced obesity

This study shows that knocking out Lyplal1 in mice leads to sex-specific protection against diet-induced obesity, mirroring human genetic findings.