Author

C. J. Meehan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Microbiology· 5 Evolutionary Biology· 3

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:statistical model· 5 Assay:whole-genome sequencing· 5 Organism:bacteria (other)· 4 Research Focus:chromatin & epigenetic regulation· 2 Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:variant calling· 2 Organism:E. coli· 1

Frequent Co-Authors

L. Rigouts· 6 shared B. C. de Jong· 4 shared D. van Soolingen· 2 shared E. Andre· 2 shared M. Behruznia· 2 shared M. R. Farhat· 2 shared S. Cogneau· 2 shared A. B. Ofori-Anyinam· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

6 shared papersMicrobiology

L. Rigouts

Mutual co-authors in cluster

Author profile →

8 papers

Recent·Most cited

The Mycobacterium tuberculosis complex pangenome is small and shaped by sub-lineage-specific regions of difference

M. Behruznia, M. Marin, D. J. Whiley, M. R. Farhat, J. C. Thomas, M. R. Domingo-Sananes, C. J. Meehan

The paper quantifies the MTBC pangenome, revealing a small, closed genome with lineage-specific regions of difference and implications for virulence and drug resistance.

bioRxiv · Mar 12, 2024Evolutionary Biology

Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species

E. Machado, S. Vasconcellos, L. Gomes, M. Catanho, J. Ramos, L. de Carvalho, T. Goldenberg, M. Dalcolmo, P. Redner, P. Caldas, C. Campos, M. C. Lourenco, E. Lasunskaia, V. Mussi, L. Spinasse, , P. Suffys

This study analyzes 665 Mycobacterium kansasii complex strains to identify unique and shared genomic signatures, revealing lineage splits, virulence factors, and drug resistance mechanisms.

bioRxiv · Feb 14, 2024Evolutionary Biology

The effect of antibiotic selection on collateral effects and evolvability of uropathogenic Escherichia coli

B. A. James, H. Reesaul, S. Kashif, M. Behruznia, C. J. Meehan, M. R. Domingo Sananes, A. T. M. Hubbard

This study examines how prior selection with trimethoprim affects collateral resistance and evolvability in uropathogenic E. coli to other UTI antibiotics.

bioRxiv · Nov 14, 2023 · PreprintMicrobiology

Reconstituting the genus Mycobacterium

C. J. Meehan, R. Barco, Y.-H. Loh, S. Cogneau, L. Rigouts

This study evaluates the proposed split of the genus Mycobacterium into five new genera and concludes that the original genus label is better supported.

bioRxiv · Mar 11, 2021Microbiology

A sister lineage of the Mycobacterium tuberculosis complex discovered in the African Great Lakes region

J. C. Semuto Ngabonziza, C. Loiseau, M. Marceau, A. Jouet, F. Menardo, O. Tzfadia, R. Antoine, E. B. Niyigena, W. Mulders, K. Fissette, M. Diels, C. Gaudin, S. Duthoy, W. Ssengooba, E. Andre, , P. J. Supply

The paper identifies a new lineage of Mycobacterium tuberculosis complex, Lineage 8, found in the African Great Lakes region, and shows its evolutionary relationship to known lineages.

bioRxiv · Jan 20, 2020Microbiology

Comparative Genomics Shows Differences in the Electron Transport and Carbon Metabolic Pathways of Mycobacterium africanum relative to Mycobacterium tuberculosis and suggests an adaptation to low oxygen tension

A. B. Ofori-Anyinam, A. Riley, T. Jobarteh, E. Gitteh, B. Sarr-Kuyateh, T. I. Faal-Jawara, L. Rigouts, M. Senghore, A. Kehinde, N. Onyejepu, M. Antonio, B. C. de Jong, F. Gehre, C. J. Meehan

The paper compares the genomes of Mycobacterium africanum and Mycobacterium tuberculosis to identify mutations in electron transport and carbon metabolic pathways, suggesting adaptations to low oxygen environments.

bioRxiv · Dec 31, 2019Microbiology

Genome wide association with quantitative resistance phenotypes in Mycobacterium tuberculosis reveals novel resistance genes and regulatory regions

M. R. Farhat, L. Freschi, R. Calderon, T. Ioerger, M. Snyder, C. J. Meehan, B. de Jong, L. Rigouts, A. Sloutsky, D. Kaur, S. Sunyaev, D. van Soolingen, J. Shendure, J. Sacchettini, M. Murray

This study identifies novel resistance genes and regulatory regions in Mycobacterium tuberculosis using genome-wide association analysis of drug resistance phenotypes.

bioRxiv · Oct 1, 2018Evolutionary Biology

Xpert Ultra can unambiguously identify specific rifampicin resistance-conferring mutations

K. C. S. Ng, A. van Deun, C. J. Meehan, G. Torrea, M. Driesen, S. Gabriels, L. Rigouts, E. Andre, B. C. de Jong

The paper evaluates Xpert Ultra's ability to identify rifampicin resistance mutations by analyzing the relationship between rpoB mutations, Ultra probes, and melting temperature shifts.

bioRxiv · May 9, 2018Microbiology