Author

D. van Soolingen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 3 Evolutionary Biology· 2

Signature Assays, Organisms & Methods

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Assay:whole-genome sequencing· 5 Approach:statistical model· 3 Research Focus:variant calling· 3 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1 Approach:experimental assay· 1 Approach:genetic perturbation / CRISPR· 1

Frequent Co-Authors

C. J. Meehan· 2 shared H. de Neeling· 2 shared L. Rigouts· 2 shared R. M. Anthony· 2 shared S. Niemann· 2 shared A. Mulder· 1 shared A. Skrahina· 1 shared A. Sloutsky· 1 shared

Activity by Year

2018-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersEvolutionary Biology

C. J. Meehan

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Author profile →

5 papers

Recent·Most cited

Phylogenomic and genomic analysis reveals unique and shared genetic signatures of Mycobacterium kansasii complex species

E. Machado, S. Vasconcellos, L. Gomes, M. Catanho, J. Ramos, L. de Carvalho, T. Goldenberg, M. Dalcolmo, P. Redner, P. Caldas, C. Campos, M. C. Lourenco, E. Lasunskaia, V. Mussi, L. Spinasse, , P. Suffys

This study analyzes 665 Mycobacterium kansasii complex strains to identify unique and shared genomic signatures, revealing lineage splits, virulence factors, and drug resistance mechanisms.

bioRxiv · Feb 14, 2024Evolutionary Biology

The appearance of sugI mixed loci in three individuals during treatment for MDR-TB, supports the involvement of sugI in Mycobacterium tuberculosis d-cycloserine resistance in vivo.

R. M. Anthony, M. Molemans, O. Akkwerman, M. G. G. Sturkenboom, A. Mulder, R. de Zwaan, D. van Soolingen, J.-W. Alffenaar, F. C. M. van Leth, S. Ghimire, N. Yastskevich, A. Skrahina, N. Ciobanu, N. Turcan, V. Crudu

This study identifies mixed SNPs in the sugI gene from M. tuberculosis isolates during MDR-TB treatment, suggesting a potential role of sugI in d-cycloserine resistance.

bioRxiv · May 30, 2023 · PreprintMicrobiology

Genetic profiling of Mycobacterium tuberculosis \"modern\" Beijing strains from Southwest Colombia

L. M. Nieto Ramirez, B. E. Ferro, G. Diaz, R. M. Anthony, D. van Soolingen, J. de Beer

The paper analyzes genetic profiles of Mycobacterium tuberculosis Beijing strains from Colombia, identifying MDR-TB and unique SNPs that suggest a distinct origin compared to strains in neighboring countries.

bioRxiv · Oct 25, 2019Microbiology

Genome wide association with quantitative resistance phenotypes in Mycobacterium tuberculosis reveals novel resistance genes and regulatory regions

M. R. Farhat, L. Freschi, R. Calderon, T. Ioerger, M. Snyder, C. J. Meehan, B. de Jong, L. Rigouts, A. Sloutsky, D. Kaur, S. Sunyaev, D. van Soolingen, J. Shendure, J. Sacchettini, M. Murray

This study identifies novel resistance genes and regulatory regions in Mycobacterium tuberculosis using genome-wide association analysis of drug resistance phenotypes.

bioRxiv · Oct 1, 2018Evolutionary Biology

A novel multi SNP based method for the identification of subspecies and associated lineages and sub-lineages of the Mycobacterium tuberculosis complex by whole genome sequencing

S. I. W. Lipworth, R. Jajou, H. de Neeling, P. Bradley, W. van der Hoek, G. Maphalala, M. Bonnet, E. Sanchez-Padilla, R. Diel, S. Niemann, Z. Iqbal, G. Smith, T. Peto, D. Crook, T. M. Walker, D. van Soolingen

This paper introduces SNP-IT, a method using whole genome sequencing to identify subspecies and lineages of Mycobacterium tuberculosis complex, revealing high prevalence of M. orygis in UK clinical isolates.

bioRxiv · Jan 5, 2018Microbiology