S. Jana

Genetic code expansion, click chemistry, and light-activated PI3K reveal details of membrane protein trafficking downstream of receptor tyrosine kinases

The paper uses optogenetic PI3K activation and genetic code expansion to study RTK signaling, showing PI3K alone can traffic TRPV1 and insulin receptors to the plasma membrane.

Phenotypic screening of covalent compound libraries identifies chloromethyl ketone antibiotics and MiaA as a new target

Isolation and characterization of a novel hormone receptor positive mammary adenocarcinoma MCa-P1362 with stromal drivers of tumor growth, metastasis, and drug resistance

The paper characterizes a novel hormone receptor positive mammary adenocarcinoma model, MCa-P1362, showing stromal-cell interactions drive tumor growth, metastasis, and drug resistance.

Combinatorial genetic strategy accelerates the discovery of cancer genotype-phenotype associations

This paper introduces a combinatorial genetic strategy to generate diverse cancer models and uses single-cell sequencing to identify polygenic drivers of cancer phenotypes.

PITAR, a DNA damage-inducible Cancer/Testis long noncoding RNA, inactivates p53 by binding and stabilizing TRIM28 mRNA

This paper identifies PITAR, a long noncoding RNA that inactivates p53 by stabilizing TRIM28 mRNA, and shows its role in glioblastoma progression and resistance to chemotherapy.

Ultra-Fast Bioorthogonal Spin-Labeling and Distance Measurements in Mammalian Cells Using Small, Genetically Encoded Tetrazine Amino Acids

This paper introduces a fast bioorthogonal reaction system for in-cell spin-labeling and DEER spectroscopy, enabling structural studies of proteins in live mammalian cells.

Probing the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy

This study investigates the role of macromolecular crowding in cell volume regulation using fluorescence anisotropy and finds that cytoplasmic MMC is not a sensor for volume regulation, while membrane tension is critical.