C. S. C. Hardy

A comparative analysis of the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models

This study compares the immunotranscriptomic features of DENV-1, -3, and -4 human challenge models to identify gene expression patterns associated with RNAemia and clinical symptoms.

HSV-1 Infection Alters MAPT Splicing and Promotes Tau Pathology in Neural Models of Alzheimer's Disease

This study shows HSV-1 infection alters MAPT splicing, increases 4R-Tau protein and hyperphosphorylation, and promotes Tau pathology in neural models.

Antibody-dependent DENV infection induces distinct transcriptomic responses in infected and bystander human macrophages

This study uses scRNA-seq to compare transcriptomic responses of DENV-infected and bystander macrophages under ADE and conventional infection, revealing distinct gene expression patterns and pathways.

B cell receptor dependent enhancement of dengue virus infection

This study shows that DENV infection enhances B cells via their BCR, linking ADE potential to B cell susceptibility and highlighting B cells as a key reservoir in immune-mediated DENV enhancement.