S. Pelletier

Inducible genetic ablation of Immt induces a lethal disruption of the MICOS complex

This study shows that deleting Immt, which encodes MIC60, in mice causes lethal disruption of the MICOS complex, leading to intestinal defects and bone marrow issues.

Y-complex nucleoporins independently contribute to nuclear pore assembly and gene regulation in neuronal progenitors

The paper shows Y-complex nucleoporins regulate gene expression in neuronal progenitors independently of nuclear pore basket assembly.

Determining distinct roles of IL-1α through generation of an IL-1α knockout mouse with no defect in IL-1β expression

The paper generates a new IL-1α knockout mouse line (Il1a-KOline2) that maintains normal IL-1β expression, revealing IL-1's independent role in neutrophil chemoattractant production.

Neuroblastoma formation requires unconventional CD4 T cells and myeloid amino acid metabolism

This study identifies unconventional CD4 T cells and myeloid amino acid metabolism as critical for neuroblastoma formation using a mouse model and spatial transcriptomics.

A blueprint of seed desiccation sensitivity in the genome of Castanospermum australe

This study sequenced the genome of Castanospermum australe, a desiccation-sensitive legume, and found that its seeds remain metabolically active and lack mechanisms for desiccation tolerance.