Author

C. T. Lefort

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 3 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:host-pathogen & immune response· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 2 Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Research Focus:development & morphogenesis· 2 Approach:deep learning· 1

Frequent Co-Authors

B. M. Neumann· 3 shared Z. S. Wilson· 3 shared A. Ayala· 1 shared A. Chorzalska· 1 shared A. M. Fredericks· 1 shared A. Whitman· 1 shared C. Franck· 1 shared E. M. Darling· 1 shared

Activity by Year

2019-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 16 mutual co-author links

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3 shared papersImmunology

B. M. Neumann

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification and Mechanistic Basis of non-ACE2 Blocking Neutralizing Antibodies from COVID-19 Patients with Deep RNA Sequencing and Molecular Dynamics Simulations

A. M. Fredericks, K. W. East, Y. Shi, J. Liu, F. Maschietto, A. Ayala, W. G. Cioffi, M. Cohen, W. G. Fairbrother, C. T. Lefort, G. J. Nau, M. M. Levy, J. Wang, V. S. Batista, G. P. Lisi, S. F. Monaghan

The paper identifies non-ACE2 blocking neutralizing antibodies in COVID-19 patients using deep RNA sequencing and molecular dynamics simulations, showing their potential for personalized therapy.

bioRxiv · Jun 29, 2022Immunology

Vinculin plays a role in neutrophil stiffening and transit through model capillary segments

B. M. Neumann, Z. S. Wilson, K. Auguste, Y. Roye, M. K. Shah, E. M. Darling, C. T. Lefort

This study shows vinculin is essential for neutrophil stiffening and sequestration in pulmonary capillaries, using microfluidic assays and atomic force microscopy.

bioRxiv · Apr 24, 2022 · PreprintCell Biology

Engraftment, fate, and function of HoxB8-conditional neutrophil progenitors in the unconditioned murine host

J. T. Cohen, M. Danise, K. D. Hinman, B. M. Neumann, R. Johnson, Z. S. Wilson, A. Chorzalska, P. M. Dubielecka, C. T. Lefort

This study shows HoxB8-conditional neutrophil progenitors can engraft in naive mice without niche conditioning, generate mature neutrophils, and respond to inflammation via known recruitment mechanisms.

bioRxiv · Dec 20, 2021Immunology

Context-dependent role of vinculin in neutrophil adhesion, motility and trafficking

Z. S. Wilson, H. Witt, L. Hazlett, M. Harman, B. M. Neumann, A. Whitman, M. Patel, R. S. Ross, C. Franck, J. S. Reichner, C. T. Lefort

This study investigates the role of vinculin in neutrophil adhesion, motility, and trafficking, finding that it partially affects adhesion and spreading but is dispensable for recruitment in vivo.

bioRxiv · Nov 20, 2019Immunology