Author

Sanya Aggarwal

University of Cambridge

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Approach:statistical model· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Florian T. MerkleiD· 3 shared Andrian YangiD· 2 shared Christine RowleyiD· 2 shared Deborah Kronenberg‐VersteegiD· 2 shared Hsiao‐Jou Cortina CheniD· 2 shared John C. MarioniiD· 2 shared Marc WelzeriD· 2 shared Peter KirwaniD· 2 shared

Activity by Year

2022-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 43 mutual co-author links

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3 shared papersNeuroscience

Florian T. MerkleORCID

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3 papers

Recent·Most cited

Metformin acts directly in the brain to slow features of neurodegeneration.

Edward C. Harding, Hsiao‐Jou Cortina Chen, Dmytro Shepilov, Marc Welzer, Viviana Macarelli, Alix Schwiening, Christine Rowley, Sanya Aggarwal, Dean Swinden, Deborah Kronenberg‐Versteeg, Florian T. Merkle

This study shows metformin can slow neurodegeneration features in mice, even in metabolically healthy individuals, by acting directly in the brain.

bioRxiv · Jul 18, 2023 · PreprintNeuroscience

Profiling human hypothalamic neurons reveals a candidate combination drug therapy for weight loss

Hsiao‐Jou Cortina Chen, Andrian Yang, Simone Mazzaferro, Iman D. Mali, Olivier Cahn, Katherine A. Kentistou, Christine Rowley, Natasha M. Stewart, Jun Wen Eugene Seah, Venkat Pisupati, Peter Kirwan, Sanya Aggarwal, Takafumi Toyohara, Mary H.C. Florido, Chad A. Cowan, , Florian T. Merkle

The paper identifies a drug combination targeting human POMC neurons to reduce food intake and body weight using hPSC-derived neurons and mouse models.

bioRxiv · Jul 18, 2023 · PreprintNeuroscience

A reference induced pluripotent stem cell line for large-scale collaborative studies

Caroline B. Pantazis, Andrian Yang, Erika Lara, Justin A. McDonough, Cornelis Blauwendraat, Lirong Peng, Hideyuki Oguro, Jitendra Kumar Kanaujiya, Jizhong Zou, David P. Sebesta, Gretchen Pratt, Erin Cross, Jeffrey Blockwick, Philip Buxton, Lauren Kinner-Bibeau, , Florian T. Merkle

The paper identifies and characterizes a reference iPSC line, KOLF2.1J, for standardized use in collaborative studies across multiple differentiation protocols and assays.

Cell stem cell · Dec 1, 2022Peer-reviewedNeuroscience