ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells
Luisa Bell, Shane Clerkin, Filiz Sila Rizalar, A. Rizkallah, Nadine Stokar‐Regenscheit, Xandor M. Spijkers, Nienke R. Wevers, Claire Simonneau, Angélique Augustin, Barbara Höllbacher, Lia D’Abate, Joanna Ficek, Kim Schneider, Désirée von Tell, Thomas L. Maurissen, , Roberto Villaseñor
The paper investigates how ApoE4 affects intracellular trafficking and iron homeostasis in human brain endothelial cells derived from iPSCs, showing altered endosomal organization and iron levels.
Stem Cell Reports · Aug 21, 2025Peer-reviewedCell Biology