Author

Nienke R. Wevers

Mimetas (Netherlands)ORCID 0000-0002-0693-3085Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

A. Rizkallah· 1 shared Alex OdermattiD· 1 shared Angélique Augustin· 1 shared Barbara HöllbacheriD· 1 shared Chiara Zanini· 1 shared Christelle Zundel· 1 shared Christine BeckeriD· 1 shared Claire Simonneau· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperCell Biology

A. Rizkallah

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2 papers

Recent·Most cited

Building the blood-brain barrier: a scalable self-assembling 3D model of the brain microvasculature under unidirectional flow

Jade Admiraal, Promise Emeh, Marleen Bokkers, Sander Ruiter, Thomas Olivier, Karla C. S. Queiroz, Todd P. Burton, Nienke R. Wevers

This paper presents a scalable 3D BBB model using human cells in a microfluidic platform, showing improved barrier function with co-culture of endothelial cells, astrocytes, and pericytes.

Fluids and Barriers of the CNS · Jan 23, 2026Peer-reviewedNeuroscience

ApoE4 disrupts intracellular trafficking and iron homeostasis in an improved iPSC-based model of human brain endothelial cells

Luisa Bell, Shane Clerkin, Filiz Sila Rizalar, A. Rizkallah, Nadine Stokar‐Regenscheit, Xandor M. Spijkers, Nienke R. Wevers, Claire Simonneau, Angélique Augustin, Barbara Höllbacher, Lia D’Abate, Joanna Ficek, Kim Schneider, Désirée von Tell, Thomas L. Maurissen, , Roberto Villaseñor

The paper investigates how ApoE4 affects intracellular trafficking and iron homeostasis in human brain endothelial cells derived from iPSCs, showing altered endosomal organization and iron levels.

Stem Cell Reports · Aug 21, 2025Peer-reviewedCell Biology