Author

Claudio Cappelli Leon

Austral University of Chile

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Biochemistry· 1

Signature Assays, Organisms & Methods

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Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Alejandro Rojas‐FernándeziD· 1 shared Constanza Salinas-RebolledoiD· 1 shared David SchwefeliD· 1 shared Elizabeth Carrazana· 1 shared Francisca Díaz-TejedaiD· 1 shared Gopal P. SapkotaiD· 1 shared Guillermo ValenzuelaiD· 1 shared Ignacio Arias Catalán· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Alejandro Rojas‐FernándezORCID

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Author profile →

1 paper

Recent·Most cited

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

Constanza Salinas-Rebolledo, Javier Blesa, Guillermo Valenzuela, David Schwefel, Natalia López‐González del Rey, Maxs Méndez-Ruette, Janine Burkhalter, Elizabeth Carrazana, Francisca Díaz-Tejeda, Ignacio Arias Catalán, Claudio Cappelli Leon, Natalia Salvadores, Luis Federico Bátiz, Ronald Jara, Jose Angel Obeso, , Alejandro Rojas‐Fernández

This paper describes the engineering of a PROTAC that uses p97-directed proteolysis to achieve specific substrate degradation without relying on E3 ubiquitin ligases.

eLife · Nov 25, 2025Peer-reviewedBiochemistry