Author

Javier Blesa

HM HospitalesORCID 0000-0002-4257-1325Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Assay:proteomics· 3 Research Focus:drug response / drug discovery· 2 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Organism:non-human primate· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Alejandro Rojas‐FernándeziD· 2 shared Constanza Salinas-RebolledoiD· 2 shared David SchwefeliD· 2 shared Guillermo ValenzuelaiD· 2 shared Jose Angel ObesoiD· 2 shared Natalia López‐González del ReyiD· 2 shared Pedro Chaná‐CuevasiD· 2 shared Ronald JaraiD· 2 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersBiochemistry

Alejandro Rojas‐FernándezORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NeuroscienceNeurobiology of DiseasePeer-reviewedJun 28, 2026

Tier-specific location of Lewy body pathology and related neuromelanin levels drive dopaminergic cell vulnerability in pigmented non-human primates

Julia Chocarro, Alberto J. Rico, Goiaz Ariznabarreta…·José Luis Lanciego

This study investigates tier-specific vulnerability of dopaminergic neurons in non-human primates by analyzing Lewy body distribution and neuromelanin levels in different brain regions.

DOI 10.1016/j.nbd.2026.107513

non-human primateproteomics

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BiochemistryeLifePeer-reviewedNov 25, 2025

Specific proteolysis mediated by a p97-directed proteolysis-targeting chimera (PROTAC)

Constanza Salinas-Rebolledo, Javier Blesa, Guillermo Valenzuela…·Alejandro Rojas‐Fernández

This paper describes the engineering of a PROTAC that uses p97-directed proteolysis to achieve specific substrate degradation without relying on E3 ubiquitin ligases.

3 citations

proteomicsexperimental assay

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Molecular BiologyScientific ReportsPeer-reviewedFeb 8, 2021

Potent neutralization of clinical isolates of SARS-CoV-2 D614 and G614 variants by a monomeric, sub-nanomolar affinity Nanobody.

Guillermo Valenzuela, Ronald Jara, Daniel Watterson…·Alejandro Rojas‐Fernández

The paper describes the development of a high-affinity Nanobody against SARS-CoV-2 RBD that neutralizes wild-type and D614G variants with nanomolar potency.

57 citations

proteomicsexperimental assay

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