Ovarian Tumor FAK Inhibition Releases Omega-3 Fatty Acids Stimulating GATA6 Peritoneal Macrophage CXCL13 Production Enhancing Immunotherapy
Xiao Lei Chen, Kevin M. Tharp, Marjaana Ojalill, Duygu Ozmadenci, Antonia D. Boyer, Terrance James Haanen, Christine Lawson, James Lee, Marvin Xia, Elise Tahon, Joanna T. Zhang, Cray Minor, Safir Ullah Khan, Colin C. Anderson, Travis G. Nemkov, , David D. Schlaepfer
This study shows FAK inhibition in ovarian tumors increases macrophage CXCL13 production via omega-3 fatty acids, enhancing B cell infiltration and immunotherapy response.
bioRxiv · Sep 12, 2025 · PreprintCancer Biology