Author

Crystal R. McClain

University of Colorado Anschutz

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Assay:imaging· 1

Frequent Co-Authors

Ethan G. HughesiD· 2 shared Helena J. BarriD· 2 shared Anna WilliamsiD· 1 shared Anza DarehshouriiD· 1 shared Arlo Simmerman· 1 shared Benjamin D. SimonsiD· 1 shared Björn NeumanniD· 1 shared Civia Zi-Yu CheniD· 1 shared

Activity by Year

2020-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Ethan G. HughesORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling

Lindsay A. Osso, Helena J. Barr, Michael E. Stockton, Maureen Wentling, Stephanie Karas, Rongchen Huang, Graham C. Peet, Katherine S. Given, Arlo Simmerman, Crystal R. McClain, Mohammad Mansoor, Dustin P. Fykstra, Kellie Horan, Clara Mutschler, Connon I. Thomas, , Ethan G. Hughes

This study shows microglia drive myelin loss in MS through autoantibodies and BTK signaling, with implications for therapeutic targeting.

bioRxiv · Sep 1, 2026 · PreprintNeuroscience

Proliferation is a requirement for differentiation of oligodendrocyte progenitor cells during CNS remyelination

Sarah Foerster, Björn Neumann, Crystal R. McClain, Ludovica Di Canio, Civia Zi-Yu Chen, Daniel S. Reich, Benjamin D. Simons, Robin J.M. Franklin

This study shows that OPC proliferation is required for differentiation during CNS remyelination, revealing a link between proliferation and differentiation in OPCs.

bioRxiv · May 21, 2020 · PreprintNeuroscience

Motor Learning Promotes Remyelination via New and Surviving Oligodendrocytes

Clara M. Bacmeister, Helena J. Barr, Crystal R. McClain, Michael Andrew Thornton, Dailey Nettles, Cristin G. Welle, Ethan G. Hughes

This study shows that motor learning after partial remyelination enhances remyelination by increasing oligodendrogenesis and myelin sheath generation.

Nature Neuroscience · May 18, 2020Peer-reviewedNeuroscience