Microglia drive demyelination via multiple sclerosis antibodies and BTK signaling
Lindsay A. Osso, Helena J. Barr, Michael E. Stockton, Maureen Wentling, Stephanie Karas, Rongchen Huang, Graham C. Peet, Katherine S. Given, Arlo Simmerman, Crystal R. McClain, Mohammad Mansoor, Dustin P. Fykstra, Kellie Horan, Clara Mutschler, Connon I. Thomas, , Ethan G. Hughes
This study shows microglia drive myelin loss in MS through autoantibodies and BTK signaling, with implications for therapeutic targeting.
bioRxiv · Sep 1, 2026 · PreprintNeuroscience