Author

T. Jordan

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cancer Biology· 2 Microbiology· 2 Biophysics· 1 Immunology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell signaling & trafficking· 3 Organism:human· 3 Assay:bulk RNA-seq· 2 Research Focus:drug response / drug discovery· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:clustering· 1

Frequent Co-Authors

R. A. Albrecht· 2 shared W.-C. Liu· 2 shared Z. Zhu· 2 shared A. A. Joy· 1 shared A. Ajamu-Johnson· 1 shared A. Bryant· 1 shared A. C.-Y. Lee· 1 shared A. Garcia-Sastre· 1 shared

Activity by Year

2020-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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2 shared papersMicrobiology

R. A. Albrecht

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Pyruvate Kinase Activity Regulates Cystine Starvation Induced Ferroptosis through Malic Enzyme 1 in Pancreatic Cancer Cells

E. M. Ensink, T. Jordan, H. C. Dias de Medeiros, G. Thurston, A. Pardal, L. Yu, S. Lunt

This study shows that PKM2 knockout in pancreatic cancer cells increases resistance to cystine starvation-induced ferroptosis by reprogramming glutamine metabolism through ME1 to produce NADPH.

bioRxiv · Sep 15, 2023 · PreprintCancer Biology

Contact area and tissue growth dynamics shape synthetic juxtacrine signaling patterns

J. Dawson, A. Bryant, T. Jordan, S. Bhikot, S. Macon, B. Walton, A. Ajamu-Johnson, P. D. Langridge, A. N. Malmi-Kakkada

The paper investigates how cell-cell contact area and tissue growth dynamics influence synthetic juxtacrine signaling patterns using a custom gene circuit in Drosophila wing imaginal discs and mathematical modeling.

bioRxiv · Jul 12, 2023Biophysics

Stress granules are shock absorbers that prevent excessive innate immune responses to dsRNA

S. Hur, M. Paget, C. Cadena, S. Ahmad, H. Wang, T. Jordan, E. Kim, Q. Zhang, B. Koo, S. Lyons, P. Ivanov, B. tenOever, X. Mu

This study shows stress granules regulate immune responses to dsRNA by preventing excessive inflammation and viral replication.

bioRxiv · Apr 26, 2021Immunology

Topoisomerase 1 inhibition therapy protects against SARS-CoV-2-induced inflammation and death in animal models.

J. S. Y. Ho, B. W.-Y. Mok, L. Campisi, T. Jordan, S. Yildiz, S. Parameswaran, J. A. Wayman, N. N. Gaudreault, D. A. Meekins, S. V. Indran, I. Morozov, J. D. Trujillo, Y. S. Fstkchyan, R. Rathnasinghe, Z. Zhu, , Jeya

This study shows that Top1 inhibition with Topotecan reduces SARS-CoV-2-induced inflammation and mortality in animal models.

bioRxiv · Dec 1, 2020 · PreprintMicrobiology

Human organ chip-enabled pipeline to rapidly repurpose therapeutics during viral pandemics

L. Si, H. Bai, M. Rodas, W. Cao, C. Y. Oh, A. Jiang, R. Moller, D. Hoagland, K. Oishi, S. Horiuchi, S. Uhl, D. Blanco-Melo, R. A. Albrecht, W.-C. Liu, T. Jordan, , D. E. Ingber

This paper demonstrates the use of human organ chips to rapidly repurpose therapeutics for viral pandemics, identifying amodiaquine as a potential treatment for SARS-CoV-2.

bioRxiv · Apr 13, 2020 · PreprintMicrobiology

Genome profiles of lymphovascular breast cancer cells reveal multiple clonally differentiated outcomes with multi-regional LCM and G&T-seq

Z. Zhu, W. Wang, F. Lin, T. Jordan, G. Li, S. Silverman, S. Qiu, A. A. Joy, C. Chen, D. Hockley, X. Zhang, Q. Zhou, L.-M. Postovit, X. Zhang, Y. Hou, , G. K.-S. Wong

This study isolates lymphovascular breast cancer cells using LCM and G&T-seq to identify three distinct clonal pathways associated with different survival outcomes and ribosomal protein downregulation as a poor prognosis marker.

bioRxiv · Feb 1, 2020Cancer Biology