Author

K. M. Suen

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 4 Biochemistry· 2 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Research Focus:cell type annotation· 4 Organism:C. elegans· 3 Research Focus:cell signaling & trafficking· 3 Assay:imaging· 2 Research Focus:protein folding & dynamics· 2 Assay:proteomics· 2 Approach:biophysical modeling· 1

Frequent Co-Authors

C.-C. Lin· 5 shared J. E. Ladbury· 5 shared E. A. Miska· 3 shared L. Wieteska· 3 shared Z. Ahmed· 3 shared A. I. Lamond· 2 shared D. Bensaddek· 2 shared I. Jayasinghe· 2 shared

Activity by Year

2019-2023 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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5 shared papersCell Biology

C.-C. Lin

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Author profile →

7 papers

Recent·Most cited

Differential labelling of human sub-cellular compartments with fluorescent dye esters and expansion microscopy

T. M. D. Sheard, T. Shakespeare, R. S. Seehra, M. E. Spencer, K. M. Suen, I. Jayasinghe

The paper evaluates 14 fluorescent dye esters for their ability to label human sub-cellular compartments using expansion microscopy, finding differential staining patterns and specificity influenced by dye properties and experimental conditions.

bioRxiv · Feb 21, 2023Cell Biology

Expansion microscopy reveals subdomains in C. elegans germ granules

K. M. Suen, T. M. D. Sheard, C.-C. Lin, D. Milonaityte, I. Jayasinghe, J. E. Ladbury

This study uses expansion microscopy to reveal subdomains within C. elegans P granules and their relationship to other germ granules.

bioRxiv · May 29, 2022Cell Biology

Receptor tyrosine kinases regulate signal transduction through a liquid-liquid phase separated state

C.-C. Lin, K. M. Suen, P.-A. Jeffrey, L. Wieteska, A. Stainthorp, C. Seiler, H. Koss, C. Molina-Paris, E. A. Miska, Z. Ahmed, J. E. Ladbury

This study shows that RTKs form liquid-liquid phase-separated states with downstream effectors to enhance signaling fidelity.

Molecular Cell · Mar 1, 2022Peer-reviewedCell Biology

Identification of putative reader proteins of 5-methylcytosine and its derivatives in Caenorhabditis elegans RNA

I. C. Navarro, K. M. Suen, D. Bensaddek, A. Tanpure, A. I. Lamond, S. Balasubramanian, E. A. Miska

The paper identifies reader proteins for 5-methylcytosine and its derivatives in C. elegans RNA using modified RNA baits and mass spectrometry.

bioRxiv · Jan 24, 2022Biochemistry

Regulation of kinase activity by combined action of juxtamembrane and C-terminal regions of receptors

C.-C. Lin, L. Wieteska, G. Poncet-Montange, K. M. Suen, S. T. Arold, z. ahmed, J. E. Ladbury

The paper investigates how juxtamembrane and C-terminal regions regulate kinase activity in RTKs, identifying key interactions and mutations linked to disease.

bioRxiv · Oct 1, 2020 · PreprintBiochemistry

Grb2 binding induces phosphorylation-independent activation of Shp2

C.-C. Lin, L. Wieteska, K. M. Suen, A. Kalverda, Z. Ahmed, J. E. Ladbury

This study shows Grb2 binding activates Shp2 independently of phosphorylation, and identifies a peptide that blocks this interaction, reducing Shp2 activity and MAPK signaling.

bioRxiv · Nov 29, 2019Cancer Biology

Direct interaction of PIWI and DEPS-1 is essential for piRNA function and condensate ultrastructure in Caenorhabditis elegans

K. M. Suen, F. Braukmann, R. Butler, D. Bensaddek, A. Akay, C.-C. Lin, N. Doshi, A. Sapetschnig, A. I. Lamond, J. E. Ladbury, E. A. Miska

The paper investigates how PIWI and DEPS-1 interact to support piRNA function and condensate structure in C. elegans.

bioRxiv · Mar 16, 2019 · PreprintCell Biology