Author

Y.-S. Leo

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 5 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:human· 6 Research Focus:host-pathogen & immune response· 5 Assay:proteomics· 3 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1 Research Focus:database / resource· 1

Frequent Co-Authors

B. Lee· 4 shared L. Renia· 4 shared S. N. Amrun· 4 shared B. E. Young· 3 shared D. C. Lye· 3 shared G. Carissimo· 3 shared L. F. Ng· 3 shared N. K.-W. Yeo· 3 shared

Activity by Year

2017-2021 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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4 shared papersImmunology

B. Lee

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Data-driven analysis of COVID-19 reveals specific severity patterns distinct from the temporal immune response

J. Lim, G. Carissimo, Y.-H. Chan, S.-W. Fong, W. W. Lee, S.-Y. Tan, D. C. Lye, B. E. Young, L. Renia, L. Fong-Poh NG, O. Rotzschke, K. J. Puan, L. W. Wang, K. W. W. Teng, C. Y. Loh, , B. Lee

The paper identifies immune signatures associated with COVID-19 severity and temporality, revealing distinct patterns and providing tools for data analysis.

bioRxiv · Feb 10, 2021 · PreprintImmunology

Whole blood immunophenotyping uncovers immature neutrophil-to-VD2 T-cell ratio as an early prognostic marker for severe COVID-19

G. Carissimo, W. Xu, I. Kwok, M. Y. Abdad, Y. H. Chan, S. W. Fong, K. J. Puan, C. Y. P. Lee, N. K.-W. Yeo, S. N. Amrun, R. S.-L. Chee, W. How, S. Chan, E. B. Fan, A. Andiappan, , L. F. Ng

The paper identifies an immature neutrophil-to-VD2 T-cell ratio as a prognostic marker for severe COVID-19 using flow cytometry data.

bioRxiv · Jun 11, 2020Immunology

Potent neutralizing antibodies in the sera of convalescent COVID-19 patients are directed against conserved linear epitopes on the SARS-CoV-2 spike protein

C. M. Poh, G. Carissimo, W. Bei, S. N. Amrun, C. Y.-P. Lee, R. S.-L. Chee, N. K.-W. Yeo, W.-H. Lee, Y.-S. Leo, M. I.-C. Chen, S.-Y. Tan, L. Y. A. Chai, S. Kalimuddin, S.-Y. Thien, B. E. Young, , L. F. Ng

The paper identifies two immunodominant linear epitopes on the SARS-CoV-2 spike protein that are targets of potent neutralizing antibodies in convalescent patient sera.

bioRxiv · Mar 30, 2020Immunology

Discovery of a 382-nt deletion during the early evolution of SARS-CoV-2

Y. Su, D. Anderson, B. Young, F. Zhu, M. Linster, S. Kalimuddin, J. Low, Z. Yan, J. Jayakumar, L. Sun, G. Yan, I. Mendenhall, Y.-S. Leo, D. Lye, L.-F. Wang, G. Smith

The paper identifies a 382-nt deletion in SARS-CoV-2 ORF8 from Singapore patients, which enhances N gene transcription and may contribute to viral attenuation.

bioRxiv · Mar 11, 2020 · PreprintMicrobiology

Novel differential linear B-cell epitopes to identify Zika and dengue virus infections in patients

S. N. Amrun, W.-X. Yee, F. Abu Bakar, B. Lee, Y.-W. Kam, F.-M. Lum, J. J. L. Tan, V. W. X. Lim, W. Watthanaworawit, C. Ling, F. Nosten, L. Renia, Y.-S. Leo, L. F. P. Ng

The paper identifies differential linear B-cell epitopes to distinguish Zika and Dengue virus infections, showing high sensitivity and specificity in patient samples.

bioRxiv · May 16, 2019Immunology

Zika virus infection preferentially counterbalances human peripheral monocyte and/or NK-cell activity

F. M. Lum, D. Lee, T.-K. Chua, J. J. Tan, C. Y. Lee, X. Liu, Y. Fang, B. Lee, W.-X. Yee, N. Rickett, P.-Y. Chia, V. Lim, Y.-S. Leo, D. Matthews, J. Hiscox, L. F. Ng

This study investigates how ZIKV infection affects monocyte and NK-cell activity through transcriptomic and immunoproteomic analyses, revealing counterbalancing effects on immune responses.

bioRxiv · Dec 5, 2017Immunology