Author

D. C. Spierings

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

Click to filter author papers

Cancer Biology· 2 Cell Biology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:cancer & tumor microenvironment· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Assay:whole-genome sequencing· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:differential expression· 1

Frequent Co-Authors

F. Foijer· 3 shared B. Bakker· 2 shared M. Schubert· 2 shared R. Wardenaar· 2 shared A. C. Bolhaqueiro· 1 shared A. E. Tijhuis· 1 shared A. Mark· 1 shared B. Vitre· 1 shared

Activity by Year

2020-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCancer Biology

F. Foijer

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Predicting CIN rates from single-cell whole genome sequencing data using an in silico model

B. Bakker, M. Schubert, A. C. Bolhaqueiro, G. J. Kops, D. C. Spierings, F. Foijer

The paper develops an in silico model, CINsim, to predict chromosomal instability (CIN) rates from single-cell whole genome sequencing data by simulating karyotype dynamics and validating it in mouse and human cancer models.

bioRxiv · Feb 14, 2023 · PreprintCancer Biology

Short-term molecular consequences of chromosome mis-segregation for genome stability

L. Garribba, G. De Feudis, V. Martis, M. Galli, M. Dumont, Y. Eliezer, R. Wardenaar, M. R. Ippolito, D. R. Iyer, A. E. Tijhuis, D. C. Spierings, M. Schubert, S. Taglietti, C. Soriani, S. Gemble, , S. Santaguida

This study shows that aneuploidy can trigger chromosome instability (CIN) by causing DNA replication stress and continuous CIN, leading to genetically diverse cells with varying proliferation abilities.

bioRxiv · Jun 19, 2022Cell Biology

Transient genomic instability drives tumorigenesis through accelerated clonal evolution

O. Shoshani, B. Bakker, Y. Wang, D. H. Kim, M. Maldonado, M. A. Demarest, J. Artates, O. Zhengyu, A. Mark, R. Wardenaar, R. Sasik, D. C. Spierings, B. Vitre, K. Fisch, F. Foijer, D. W. Cleveland

This study compares chronic and transient chromosomal instability in mice, showing that transient instability accelerates tumor formation through rapid clonal evolution.

bioRxiv · Nov 17, 2020Cancer Biology