Z. Dou

Linked regulation of genome integrity and senescence-associated inflammation by p53

This study identifies a mitochondria-regulated p53 circuit that links genomic instability and inflammation in senescent cells, showing p53 suppresses inflammation without affecting cell cycle arrest.

Toxoplasma gondii harbors a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein.

This study identifies a hypoxia-responsive coproporphyrinogen dehydrogenase-like protein in Toxoplasma gondii that exhibits enzymatic activity but does not affect intracellular growth under hypoxia.

A cathepsin C-like protease post-translationally modifies Toxoplasma gondii secretory proteins for optimal invasion and egress.

This study identifies TgCPC1, a cathepsin C-like protease in Toxoplasma gondii, as essential for the post-translational modification of micronemal proteins required for invasion and egress.

Nuclear autophagy interactome unveils WSTF as a constitutive nuclear inhibitor of inflammation

The paper identifies WSTF as a nuclear inhibitor of inflammation degraded by autophagy, showing its role in inflammation, cancer, and immune surveillance.

Safe, effective, and inexpensive clearance of mycoplasma contamination from cultures of apicomplexan parasites with Sparfloxacin.

This study identifies Sparfloxacin as a safe, effective, and inexpensive alternative to clear mycoplasma contamination from apicomplexan parasite cultures.

The vacuolar iron transporter mediates iron detoxification in Toxoplasma gondii

This study identifies the vacuolar iron transporter (VIT) in Toxoplasma gondii as essential for iron detoxification, showing its role in managing iron levels and parasite survival.

Toxoplasma gondii requires its plant-like heme biosynthesis pathway for infection.

This study shows Toxoplasma gondii relies on its plant-like heme biosynthesis pathway for infection and demonstrates oxadiazon and its derivatives inhibit growth, suggesting heme biosynthesis as a therapeutic target.

Toxoplasma Cathepsin Protease B and Aspartyl Protease 1 play recessive roles in endolysosomal protein digestion during infection

This study shows that CPL is the dominant protease in Toxoplasma gondii's VAC, while CPB and ASP1 have dispensable roles in protein digestion.

An ortholog of P. falciparum chloroquine resistance transporter (PfCRT) plays a key role in maintaining the integrity of the endolysosomal system in Toxoplasma gondii to facilitate host invasion

This study identifies TgCRT as a key regulator of the endolysosomal system in Toxoplasma gondii, showing its role in maintaining VAC integrity and facilitating parasite invasion.