M. O. Steinmetz

VASH1-SVBP and VASH2-SVBP generate different detyrosination profiles on microtubules

This paper shows VASH1-SVBP and VASH2-SVBP generate distinct detyrosination patterns on microtubules through different molecular mechanisms.

Microtubule plus-end regulation by centriolar cap proteins

The paper investigates how CP110 and CEP97 regulate microtubule plus-end dynamics and centriole biogenesis through direct interactions and synergistic effects.

High interaction valency ensures cohesion and persistence of a microtubule +TIP body at the plus-end of a single specialized microtubule in yeast

The paper investigates the Kar9 network in yeast, showing it forms a multivalent, liquid-like condensate at microtubule tips that persists during growth and shrinkage and functions as a mechanical coupling device.

Structural insight into the stabilization of microtubules by taxanes

This study determines the crystal structures of taxane-tubulin complexes and uses simulations to elucidate how taxanes stabilize microtubules through conformational changes and ligand binding.

Changes in seam number and location induce holes within microtubules assembled from porcine brain tubulin and in Xenopus egg cytoplasmic extracts

The paper examines microtubule structure in porcine brain tubulin and Xenopus egg extracts, finding variable seam numbers and locations that create lattice holes.

In vivo photocontrol of microtubule dynamics and integrity, migration and mitosis, by the potent GFP-imaging-compatible photoswitchable reagents SBTubA4P and SBTub2M

This paper introduces two new photoswitchable reagents for in vivo control of microtubule dynamics and related processes, showing their effectiveness in 3D systems and model organisms.

The mechanism of selective kinesin inhibition by kinesin binding protein.

This study identifies how kinesin binding protein selectively inhibits specific kinesins by structurally distorting their motor domains and blocking microtubule attachment.

WDR90 is a centriolar microtubule wall protein important for centriole architecture integrity.

This study identifies WDR90 as a centriolar microtubule wall protein essential for maintaining centriole structure in human and Chlamydomonas cells.

Pharmaceutical-grade Rigosertib is a Microtubule-destabilizing Agent

This paper shows pharmaceutical-grade rigosertib, with high purity, causes microtubule destabilization in cells, confirming its mechanism of action against cancer cells.

Mechanisms of motor-independent membrane remodeling driven by dynamic microtubules

This study reconstitutes membrane tubulation using dynamic microtubules and proteins, revealing three motor-independent mechanisms for membrane remodeling.

Photoswitchable microtubule inhibitors enabling robust, GFP-orthogonal optical control over the tubulin cytoskeleton

The paper introduces photoswitchable microtubule inhibitors that enable optical control over microtubule dynamics using a novel scaffold with improved chemical and biochemical properties.

Structural determinants of microtubule minus end preference in CAMSAP CKK domains

This study compares human and Naegleria CKK domains to show how structural differences in tubulin conformations enable microtubule minus-end recognition.

MAP7 family proteins regulate kinesin-1 recruitment and activation

The paper shows that MAP7 family proteins activate kinesin-1 by enhancing its microtubule binding and processivity through transient interactions.