Author

M. A. Cottam

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Immunology· 4 Bioengineering· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 6 Organism:mouse· 6 Research Focus:cell type annotation· 5 Assay:scRNA-seq· 4 Research Focus:differential expression· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:cell-cell communication· 2 Research Focus:host-pathogen & immune response· 2

Frequent Co-Authors

A. H. Hasty· 3 shared H. L. Caslin· 3 shared A. Christofides· 1 shared A. Hasty· 1 shared A. M. Betjemann· 1 shared A. M. Hasty· 1 shared A. R. King· 1 shared B. I. Reinfeld· 1 shared

Activity by Year

2020-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 10 mutual co-author links

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3 shared papersImmunology

A. H. Hasty

Mutual co-authors in cluster

Author profile →

6 papers

Recent·Most cited

Single cell RNA-sequencing suggests a novel lipid associated mast cell population following weight cycling

M. Kapadia, A. M. Betjemann, M. A. Cottam, M. Mashayekhi, H. J. Silver, A. Hasty, H. L. Caslin

The paper identifies a novel lipid-associated mast cell population in weight-cycled mice and humans, linked to weight variance and potential disease roles.

bioRxiv · Nov 12, 2023 · PreprintImmunology

Caloric restriction promotes beta cell longevity and delays aging and senescence by enhancing cell identity and homeostasis mechanisms.

C. d. Santos, S. Shrestha, M. A. Cottam, G. Perkins, V. Lev-Ram, B. Roy, C. Acree, K.-Y. Kim, T. Deerinck, M. Cutler, D. Dean, J. P. Cartailler, P. E. MacDonald, M. W. Hetzer, M. H. Ellisman, R. Arrojo e Drigo

This study shows caloric restriction enhances beta cell identity and homeostasis, delays aging and senescence, and improves mitochondrial function in pancreatic beta cells.

bioRxiv · Aug 23, 2023 · PreprintCell Biology

PD-1 is induced on tumor-associated macrophages in obesity to directly restrain anti-tumor immunity

J. E. Bader, M. M. Wolf, M. Z. Madden, B. I. Reinfeld, E. N. Arner, E. S. Hathaway, K. K. Steiner, G. A. Needle, M. D. Landis, M. A. Cottam, X. Ye, A. Christofides, V. A. Boussiotis, S. M. Haake, K. E. Beckermann, , J. C. Rathmell

This study shows obesity induces PD-1 on tumor-associated macrophages, which suppresses anti-tumor immunity by altering metabolic and functional properties of these cells.

bioRxiv · Nov 12, 2022 · PreprintImmunology

Weight cycling induces innate immune memory in adipose tissue macrophages

H. L. Caslin, M. A. Cottam, J. M. Pinon, L. Y. Boney, A. H. Hasty

The paper shows weight cycling primes adipose macrophages for enhanced inflammation, worsening glucose tolerance after weight regain.

bioRxiv · Jul 2, 2022 · PreprintImmunology

Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and subsequent weight regain.

M. A. Cottam, H. L. Caslin, N. C. Winn, A. H. Hasty

This study uses multi-omics to show that obesity-related immune cell changes in adipose tissue persist during weight loss and weight regain in mice.

bioRxiv · Aug 20, 2021 · PreprintImmunology

Kupffer Cell Release of Platelet Activating Factor Drives Dose Limiting Toxicities of Nucleic Acid Nanocarriers

M. A. Jackson, S. S. Patel, F. Yu, M. A. Cottam, E. B. Glass, B. R. Dollinger, E. N. Hoogenboezem, P. Patil, D. D. Liu, I. B. Kelly, S. K. Bedingfield, A. R. King, R. E. Miles, A. M. Hasty, T. D. Giorgio, C. L. Duvall

This paper identifies Kupffer cell release of platelet activating factor (PAF) as a key driver of nanocarrier toxicity and shows that PAFR inhibition prevents dose-limiting toxicities in mice.

bioRxiv · Feb 11, 2020Bioengineering