D. E. Heinrichs

The Staphylococcus aureus iron-regulated surface determinant A (IsdA) increases SARS CoV-2 replication by modulating JAK-STAT signaling

This paper shows that Staphylococcus aureus IsdA enhances SARS CoV-2 replication by modulating JAK-STAT signaling in co-infected cells.

In vivo growth of Staphylococcus lugdunensis is facilitated by the concerted function of heme and non-heme iron acquisition mechanisms

This study identifies the iron acquisition mechanisms used by Staphylococcus lugdunensis during infection, showing that both heme and non-heme iron systems are required for proliferation in mice.

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function

This study shows that staphylococcal superantigens increase S. aureus bloodstream infection severity by inducing high IFNγ production, which impairs macrophage function and allows bacterial survival.

Heme-dependent siderophore utilization promotes iron-restricted growth of the Staphylococcus aureus hemB small colony variant

This study shows that heme-dependent siderophore utilization is critical for iron acquisition by hemB S. aureus SCVs, enabling growth under iron restriction and in vivo.

Identification of key determinants of Staphylococcus aureus vaginal colonization

This study identifies fibrinogen binding and iron acquisition as key determinants of MRSA vaginal colonization using a mouse model and transcriptomic analysis.