Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function
S. W. Tuffs, M. I. Goncheva, S. X. Xu, H. C. Craig, K. J. Kasper, J. Choi, R. S. Flannagan, S. M. Kerfoot, D. E. Heinrichs, J. K. McCormick
This study shows that staphylococcal superantigens increase S. aureus bloodstream infection severity by inducing high IFNγ production, which impairs macrophage function and allows bacterial survival.
bioRxiv · Aug 17, 2021Microbiology