Author

J. K. McCormick

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Microbiology· 5

Signature Assays, Organisms & Methods

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Approach:experimental assay· 5 Research Focus:host-pathogen & immune response· 5 Organism:human· 4 Organism:mouse· 3 Research Focus:cell signaling & trafficking· 2 Research Focus:development & morphogenesis· 2 Assay:proteomics· 2 Research Focus:cell type annotation· 1

Frequent Co-Authors

C. S. Maduta· 2 shared H. C. Craig· 2 shared K. Dufresne· 2 shared K. J. Kasper· 2 shared S. W. Tuffs· 2 shared A. J. Cork· 1 shared B. A. Shannon· 1 shared B. L. Schulz· 1 shared

Activity by Year

2020-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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2 shared papersMicrobiology

C. S. Maduta

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

Discovery of an anti-virulence compound that targets the Staphylococcus aureus SaeRS two-component system to inhibit toxic shock syndrome toxin 1 (TSST-1) production

K. Dufresne, D. A. DiMaggio, C. S. Maduta, S. R. Brinsmade, J. K. McCormick

The paper identifies PP-HCl as an anti-virulence compound that inhibits TSST-1 production in S. aureus without affecting bacterial growth or vaginal microbiota.

bioRxiv · Feb 27, 2024 · PreprintMicrobiology

Vaginal Community State Types (CSTs) Alter Environmental Cues and Production of the Staphylococcus aureus Toxic Shock Syndrome Toxin-1 (TSST-1)

C. S. Maduta, J. K. McCormick, K. Dufresne

This study shows that vaginal microbiota community state types (CSTs) influence Staphylococcus aureus TSST-1 production, with L. jensenii inhibiting it and 'unhealthy' CSTs promoting it.

bioRxiv · Jul 24, 2023 · PreprintMicrobiology

The Streptococcus pyogenes hyaluronic acid capsule promotes experimental nasal and skin infection by preventing neutrophil-mediated clearance

J. R. Hurst, B. A. Shannon, H. C. Craig, S. W. Tuffs, J. K. McCormick

This study shows that the hyaluronic acid capsule of Streptococcus pyogenes protects against neutrophil-mediated killing during nasal and skin infections, increasing bacterial burden.

bioRxiv · Apr 7, 2022Microbiology

Superantigens promote Staphylococcus aureus bloodstream infection by eliciting pathogenic interferon-gamma (IFNγ) production that subverts macrophage function

S. W. Tuffs, M. I. Goncheva, S. X. Xu, H. C. Craig, K. J. Kasper, J. Choi, R. S. Flannagan, S. M. Kerfoot, D. E. Heinrichs, J. K. McCormick

This study shows that staphylococcal superantigens increase S. aureus bloodstream infection severity by inducing high IFNγ production, which impairs macrophage function and allows bacterial survival.

bioRxiv · Aug 17, 2021Microbiology

Prophage exotoxins enhance colonization fitness in epidemic scarlet fever-causing Streptococcus pyogenes

S. Brouwer, T. C. Barnett, D. Ly, K. J. Kasper, D. M. De Oliveira, T. Rivera-Hernandez, A. J. Cork, L. McIntyre, M. G. Jespersen, J. Richter, B. L. Schulz, G. Dougan, V. Nizet, K.-Y. Yuen, Y. You, , M. J. Walker

This study identifies prophage-encoded exotoxins in Streptococcus pyogenes that enhance colonization fitness and pathogenesis in scarlet fever.

bioRxiv · May 17, 2020Microbiology