Author

D. E. James

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Cell Biology· 3 Cancer Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 4 Organism:human· 3 Organism:mouse· 3 Assay:proteomics· 3 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:metabolism & bioenergetics· 1

Frequent Co-Authors

K. C. Cooke· 3 shared A. S. Don· 2 shared J. G. Burchfield· 2 shared S. Madsen· 2 shared A. D. Vegas· 1 shared A. Garfield· 1 shared A. J. Hoy· 1 shared A. P. Ryan· 1 shared

Activity by Year

2020-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 31 mutual co-author links

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3 shared papersCell Biology

K. C. Cooke

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Identification of SEC61B as a novel regulator of calcium flux and platelet hyperreactivity in diabetes mellitus

Y. X. Kong, R. Rehan, C. L. Moreno, S. Madsen, Y. Zhang, H. Zhao, S. P. Cartland, C. B. Houlahan, D. Robertshaw, V. Trang, F. J. L. Ong, M. Cielesh, K. C. Cooke, M. Potter, J. Stockli, , F. H. Passam

This study identifies SEC61B as a regulator of calcium flux and platelet hyperreactivity in diabetes by linking ER stress to increased SEC61B expression and calcium leak.

bioRxiv · Feb 20, 2024 · PreprintCell Biology

Acetyl-CoA carboxylase 1-dependent lipogenesis drives breast cancer progression

K. Tan, T. Owen, H. P. McEwen, P. Simpson, A. J. Hoy, D. E. James, A. S. Don, M. J. Naylor

This study shows ACC1 drives breast cancer progression through lipogenesis, with ACC1 knockout reducing tumor growth and altering lipid profiles in both mouse models and human cells.

bioRxiv · Jul 20, 2023 · PreprintCancer Biology

Mitochondrial electron transport chain, ceramide and Coenzyme Q are linked in a pathway that drives insulin resistance in skeletal muscle

A. D. Vegas, S. Madsen, K. C. Cooke, L. Carroll, J. X. Y. Khor, N. Turner, X. Y. Lim, M. A. Astore, J. Morris, A. S. Don, A. Garfield, S. Zarini, K. A. Zemski Berry, A. P. Ryan, B. C. Bergman, , J. G. Burchfield

The paper links mitochondrial ceramide, CoQ, and the respiratory chain in a pathway driving insulin resistance in skeletal muscle, showing protective effects of reducing ceramide or supplementing CoQ.

bioRxiv · Mar 10, 2023 · PreprintCell Biology

Trafficking regulator of GLUT4-1 (TRARG1) is a GSK3 substrate

X. Duan, D. M. Norris, S. J. Humphrey, P. Yang, K. C. Cooke, W. P. Bultitude, B. L. Parker, O. J. Conway, J. G. Burchfield, J. R. Krycer, F. M. Brodsky, D. E. James, D. J. Fazakerley

This study identifies TRARG1 as a GSK3 substrate that regulates GLUT4 trafficking and insulin sensitivity through phosphorylation events.

bioRxiv · Dec 7, 2020Cell Biology